BS4097

antibody from Bioworld Technology, Inc
Targeting: IGF1R CD221, IGFIR, IGFR, JTK13, MGC18216
Provider product page for BS4097
Western blot
Immunohistochemistry

Antibody data

Product number
BS4097 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IGF 1R (phospho Y1161) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human IGF-1R around the phosphorylation site of Tyrosine 1161.
Description
Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IGF1R protein structure - BS4097 shown in red.