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- Antibody Data
- Antigen structure
- References [30]
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- Western blot [1]
- Immunoprecipitation [2]
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- Product number
- 20254-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20254-1-AP, RRID:AB_10667455
- Product name
- IGF1R Beta Chain antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IGF1R Beta Chain antibody (Cat. #20254-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Zinc-α2-glycoprotein relieved seizure-Induced neuronal glucose uptake impairment via insulin-like growth factor 1 receptor-regulated glucose transporter 3 expression.
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop.
IGF1-driven induction of GPCR kinase 2 in the primary afferent neuron promotes resolution of acute hyperalgesia.
Exogenous insulin-like growth factor 1 attenuates cisplatin-induced muscle atrophy in mice.
Thevebioside, the active ingredient of traditional Chinese medicine, promotes ubiquitin-mediated SRC-3 degradation to induce NSCLC cells apoptosis.
Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1.
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
MALAT1 knockdown inhibits hypopharyngeal squamous cell carcinoma malignancy by targeting microRNA-194.
Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7-H4 expression through the MEK/ERK signaling pathway.
Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer's disease.
Decreased Amino Acid Concentrations are Involved in Congenital Heart Disease.
Circulating IGF-1 promotes prostate adenocarcinoma via FOXO3A/BIM signaling in a double-transgenic mouse model.
The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1/PI3K/Akt/mTOR signaling pathway.
Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.
Receptor tyrosine kinase expression in high-grade gliomas before and after chemoradiotherapy.
The Long Noncoding RNA 150Rik Promotes Mesangial Cell Proliferation via miR-451/IGF1R/p38 MAPK Signaling in Diabetic Nephropathy.
miR-497 may enhance the sensitivity of non-small cell lung cancer cells to gefitinib through targeting the insulin-like growth factor-1 receptor.
Lnc-SNHG1 may promote the progression of non-small cell lung cancer by acting as a sponge of miR-497.
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis.
Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1.
miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway.
miR-194 functions as a novel modulator of cellular senescence in mouse embryonic fibroblasts.
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice.
Leptocarpin Suppresses Proliferation, Migration, and Invasion of Human Osteosarcoma by Targeting Type-1 Insulin-Like Growth Factor Receptor (IGF-1R).
MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.
Differences in IGF axis-related proteins in amniotic fluid of trisomy 21 and trisomy 18 using a multiple reaction monitoring approach.
Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells.
Peng W, Liu X, Tan C, Zhou W, Jiang J, Zhou X, Du J, Mo L, Chen L
Journal of neurochemistry 2021 May;157(3):695-709
Journal of neurochemistry 2021 May;157(3):695-709
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Qi R, Sun J, Qiu X, Zhang Y, Wang J, Wang Q, Huang J, Ge L, Liu Z
Scientific reports 2021 May 27;11(1):11237
Scientific reports 2021 May 27;11(1):11237
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
Liu AD, Zhou J, Bi XY, Hou GQ, Li SS, Chen Q, Xu H, Cao X
Clinical and translational medicine 2021 Mar;11(3):e337
Clinical and translational medicine 2021 Mar;11(3):e337
FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop.
Zhang Q, Zhou X, Wan M, Zeng X, Luo J, Xu Y, Ji L, Zhang JA, Fan P, Zhong J, Wu J
Cell death & disease 2021 Mar 15;12(3):275
Cell death & disease 2021 Mar 15;12(3):275
IGF1-driven induction of GPCR kinase 2 in the primary afferent neuron promotes resolution of acute hyperalgesia.
Takemura H, Kushimoto K, Horii Y, Fujita D, Matsuda M, Sawa T, Amaya F
Brain research bulletin 2021 Dec;177:305-315
Brain research bulletin 2021 Dec;177:305-315
Exogenous insulin-like growth factor 1 attenuates cisplatin-induced muscle atrophy in mice.
Sakai H, Asami M, Naito H, Kitora S, Suzuki Y, Miyauchi Y, Tachinooka R, Yoshida S, Kon R, Ikarashi N, Chiba Y, Kamei J
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1570-1581
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1570-1581
Thevebioside, the active ingredient of traditional Chinese medicine, promotes ubiquitin-mediated SRC-3 degradation to induce NSCLC cells apoptosis.
Yao C, Su L, Zhang F, Zhu X, Zhu Y, Wei L, Jiao X, Hou Y, Chen X, Wang W, Wang J, Zhu X, Zou C, Zhu S, Xu Z
Cancer letters 2020 Nov 28;493:167-177
Cancer letters 2020 Nov 28;493:167-177
Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1.
Xiao M, Guo J, Xie L, Yang C, Gong L, Wang Z, Cai J
Molecular cancer research : MCR 2020 Mar;18(3):436-447
Molecular cancer research : MCR 2020 Mar;18(3):436-447
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Yang S, Zhao N, Sun B, Yang Y, Hu Y, Zhao R
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
MALAT1 knockdown inhibits hypopharyngeal squamous cell carcinoma malignancy by targeting microRNA-194.
Wang H, Wang F, Ouyang W, Jiang X, Li W
Oncology letters 2020 Jul;20(1):173-182
Oncology letters 2020 Jul;20(1):173-182
Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7-H4 expression through the MEK/ERK signaling pathway.
Zhao Z, Zhang N, Li A, Zhou B, Chen Y, Chen S, Huang M, Wu F, Zhang L
Cancer letters 2020 Aug 10;485:14-26
Cancer letters 2020 Aug 10;485:14-26
Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer's disease.
Liu E, Zhou Q, Xie AJ, Li M, Zhang S, Huang H, Liuyang Z, Wang Y, Liu B, Li X, Sun D, Wei Y, Wang X, Wang Q, Ke D, Yang X, Yang Y, Wang JZ
Translational neurodegeneration 2019;8:8
Translational neurodegeneration 2019;8:8
Decreased Amino Acid Concentrations are Involved in Congenital Heart Disease.
Lai G, Li X, Zhang B, Wang L, He R, Zhao Y
Annals of nutrition & metabolism 2019;74(3):257-263
Annals of nutrition & metabolism 2019;74(3):257-263
Circulating IGF-1 promotes prostate adenocarcinoma via FOXO3A/BIM signaling in a double-transgenic mouse model.
Wang S, Wang N, Yu B, Cao M, Wang Y, Guo Y, Zhang Y, Zhang P, Yu X, Wang S, Zeng L, Liang B, Li X, Wu Y
Oncogene 2019 Sep;38(36):6338-6353
Oncogene 2019 Sep;38(36):6338-6353
The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1/PI3K/Akt/mTOR signaling pathway.
Shao P, Wang Y, Zhang M, Wen X, Zhang J, Xu Z, Hu M, Jiang J, Liu T
Ecotoxicology and environmental safety 2019 Oct 15;181:362-369
Ecotoxicology and environmental safety 2019 Oct 15;181:362-369
Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.
Zhu Y, Meng Y, Zhao Y, Zhu J, Xu H, Zhang E, Shi L, Du L, Liu G, Zhang C, Xu X, Kang X, Zhen Y, Zhang S
Colloids and surfaces. B, Biointerfaces 2019 Jul 1;179:66-76
Colloids and surfaces. B, Biointerfaces 2019 Jul 1;179:66-76
Receptor tyrosine kinase expression in high-grade gliomas before and after chemoradiotherapy.
Wang K, Huang R, Wu C, Li G, Zhao Z, Hu H, Liu Y
Oncology letters 2019 Dec;18(6):6509-6515
Oncology letters 2019 Dec;18(6):6509-6515
The Long Noncoding RNA 150Rik Promotes Mesangial Cell Proliferation via miR-451/IGF1R/p38 MAPK Signaling in Diabetic Nephropathy.
Zhang Y, Sun Y, Peng R, Liu H, He W, Zhang L, Peng H, Zhang Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(3):1410-1428
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(3):1410-1428
miR-497 may enhance the sensitivity of non-small cell lung cancer cells to gefitinib through targeting the insulin-like growth factor-1 receptor.
Ma W, Feng W, Tan J, Xu A, Hu Y, Ning L, Kang Y, Wang L, Zhao Z
Journal of thoracic disease 2018 Oct;10(10):5889-5897
Journal of thoracic disease 2018 Oct;10(10):5889-5897
Lnc-SNHG1 may promote the progression of non-small cell lung cancer by acting as a sponge of miR-497.
Li Z, Lu Q, Zhu D, Han Y, Zhou X, Ren T
Biochemical and biophysical research communications 2018 Nov 30;506(3):632-640
Biochemical and biophysical research communications 2018 Nov 30;506(3):632-640
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Yang S, Zhao N, Yang Y, Hu Y, Dong H, Zhao R
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis.
Zhao XC, Yang SH, Yan YQ, Zhang X, Zhang L, Jiao B, Jiang S, Yu ZB
BMC medical genomics 2018 Jul 11;11(1):59
BMC medical genomics 2018 Jul 11;11(1):59
Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1.
Jin H, Wang C, Jin G, Ruan H, Gu D, Wei L, Wang H, Wang N, Arunachalam E, Zhang Y, Deng X, Yang C, Xiong Y, Feng H, Yao M, Fang J, Gu J, Cong W, Qin W
Gastroenterology 2017 Sep;153(3):799-811.e33
Gastroenterology 2017 Sep;153(3):799-811.e33
miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway.
Li ZH, Xiong QY, Xu L, Duan P, Yang QO, Zhou P, Tu JH
Oncotarget 2017 May 16;8(20):32566-32575
Oncotarget 2017 May 16;8(20):32566-32575
miR-194 functions as a novel modulator of cellular senescence in mouse embryonic fibroblasts.
Xu S, Zhang B, Zhu Y, Huang H, Yang W, Huang H, Zheng HL, Liu X
Cell biology international 2017 Mar;41(3):249-257
Cell biology international 2017 Mar;41(3):249-257
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice.
Zhuang S, Jian YM, Sun YN
World journal of gastroenterology 2017 Jun 21;23(23):4233-4242
World journal of gastroenterology 2017 Jun 21;23(23):4233-4242
Leptocarpin Suppresses Proliferation, Migration, and Invasion of Human Osteosarcoma by Targeting Type-1 Insulin-Like Growth Factor Receptor (IGF-1R).
Zheng SW, Wan WG, Miao HX, Tang R, Wang B, Huang QZ, Liu WL, Zheng JP, Chen CQ, Zhong HB, Li SF, Sun CH
Medical science monitor : international medical journal of experimental and clinical research 2017 Aug 27;23:4132-4140
Medical science monitor : international medical journal of experimental and clinical research 2017 Aug 27;23:4132-4140
MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.
Zhang ZW, Guo RW, Lv JL, Wang XM, Ye JS, Lu NH, Liang X, Yang LX
Biochemical and biophysical research communications 2017 Apr 29;486(2):414-422
Biochemical and biophysical research communications 2017 Apr 29;486(2):414-422
Differences in IGF axis-related proteins in amniotic fluid of trisomy 21 and trisomy 18 using a multiple reaction monitoring approach.
Lai G, Zhang Y, Wang L, Zhang B, Zheng G, Wang X, Zhao X, Gao H, Zhao Y
Prenatal diagnosis 2014 Dec;34(12):1146-52
Prenatal diagnosis 2014 Dec;34(12):1146-52
Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells.
Tolba MF, Esmat A, Al-Abd AM, Azab SS, Khalifa AE, Mosli HA, Abdel-Rahman SZ, Abdel-Naim AB
IUBMB life 2013 Aug;65(8):716-29
IUBMB life 2013 Aug;65(8):716-29
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 20254-1-AP(IGF1R-Specific antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-IGF1R-Specific (IP:20254-1-AP, 5ug; Detection:20254-1-AP 1:400) with HeLa cells lysate 1800ug.
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IGF1R-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human IGF1R-Specific. This antibody recognizes human,mouse,rat antigen. The IGF1R-Specific antibody has been validated for the following applications: ELISA, WB, IP analysis.
