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Western blot
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 351802 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#351802, RRID:AB_10896950
- Product name
- Purified anti-human CD221 (IGF-1R)
- Antibody type
- Monoclonal
- Antigen
- IGF-1 receptor purified from human placentas
- Description
- CD221, also known as insulin-like growth factor 1 receptor (IGF1R), is a 135 kD transmembrane receptor. It is widely expressed on lymphoid and myeloid cells as well as non-haematopoietic cells. CD221 is a tyrosine kinase receptor and the ligands for CD221 are insulin-like growth factor 1 and 2 (IGF-1 and IGF-2), the polypeptide hormones similar in molecular structure to insulin. IGF-1/2 binding activates downstream PI3K and MAPK pathways and plays an important role in cell growth. Recent studies reveal its function of recruiting immune cells during tissue repair.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes were stained with purified CD221 (clone 1H7/CD221) (filled histogram) or mouse IgG1 isotype control (open histogram), followed by biotinylated anti-mouse IgG and Sav-PE.
- Conjugate
- Unconjugated
