351804

antibody from BioLegend
Targeting: IGF1R CD221, IGFIR, IGFR, JTK13, MGC18216
Provider product page for 351804
Western blot
Immunoprecipitation
Immunohistochemistry
Flow cytometry
Blocking/Neutralizing

Antibody data

Product number
351804 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#351804, RRID:AB_10900245
Product name
LEAF™ Purified anti-human CD221 (IGF-1R) [1H7/CD221]
Antibody type
Monoclonal
Antigen
IGF-1 receptor purified from human placentas
Description
CD221, also known as insulin-like growth factor 1 receptor (IGF1R), is a 135 kD transmembrane receptor. It is widely expressed on lymphoid and myeloid cells as well as non-haematopoietic cells. CD221 is a tyrosine kinase receptor and the ligands for CD221 are insulin-like growth factor 1 and 2 (IGF-1 and IGF-2), the polypeptide hormones similar in molecular structure to insulin. IGF-1/2 binding activates downstream PI3K and MAPK pathways and plays an important role in cell growth. Recent studies reveal its function of recruiting immune cells during tissue repair.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
500 µg
Concentration
1 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
IGF1R protein structure - 351804 shown in red.