BS60300

antibody from Bioworld Technology, Inc
Targeting: IL5 EDF, IL-5, TRF
Provider product page for BS60300

Antibody data

Product number
BS60300 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL 5 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human IL-5.
Description
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cellreplacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an Ï« chain that binds IL-5 with low affinity and a ÉÇ chain that does not bind IL-5, but together with the IL-5 Ï« chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the Ï« and ÉÇ chains is essential for signal transduction. Specifically, the membrane-proximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor Ï« subunit, IL-5RÏ«, is critical for the IL-5 induced proliferative response, expression of nuclear proto-oncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL5 protein structure - BS60300 shown in red.