CABT-B11479

antibody from Creative Diagnostics

Targeting: SOCS2 CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-B11479

Provider

Creative Diagnostics

Product name

Mouse anti-Human SOCS2 monoclonal antibody, clone 4F8

Antibody type

Monoclonal

Description

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

4F8

Vial size

50 _g

Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.