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Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS4106 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IkB ÉÇ (phospho S23) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic phosphopeptide derived from human IkB-ÉÇ around the phosphorylation site of Serine 23.
- Description
- The NF-°ÙB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory I°ÙB proteins.The regulation of I°ÙBÉÇ and I°ÙB÷ is similar to that of I°ÙBÏ«. However, the phosphorylation and ubiquitin-mediated degradation of these proteins occurs with much slower kinetics. IKK phosphorylation of I°ÙBÉÇ occurs at Ser19 and Ser23, while I°ÙB÷ can be phosphorylated at Ser18 and Ser22 . The human sequence of I°ÙB-ÉÇ has also been reported to contain a threonine at position 19 suggesting that phosphorylation could be Thr19/Ser23.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of p-IkB-¦Â (S23) pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysateLane3:PC12 whole cell lysate
