BS6462

antibody from Bioworld Technology, Inc
Targeting: CDK4 PSK-J3
Provider product page for BS6462
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6462 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CDK4 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CDK4.
Description
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2ÿCdk8, PCTAIRE-1ÿ3, PITALRE and PITSLRE. Cdk4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin upregulates Cdk4 activity, whereas binding to the Cdk inhibitor p16 downregulates Cdk4 activity. Activation of the Cdk4-cyclin complexes requires phosphorylation on a single threonyl residue of Cdk4, catalyzed by a Cdk-activating protein (CAK)
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CDK4 protein structure - BS6462 shown in red.