Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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- Product number
- AF2885 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse Latent TGF-beta bp4 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects mouse Latent TGF-beta bp4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) LTBP-1 and rhLTBP-2 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
AAI41006
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development.
Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts.
Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.
Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.
Fujikawa Y, Yoshida H, Inoue T, Ohbayashi T, Noda K, von Melchner H, Iwasaka T, Shiojima I, Akama TO, Nakamura T
Scientific reports 2017 Mar 2;7:43714
Scientific reports 2017 Mar 2;7:43714
Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts.
Schiavinato A, Keene DR, Imhof T, Doliana R, Sasaki T, Sengle G
Scientific reports 2017 Jul 17;7(1):5526
Scientific reports 2017 Jul 17;7(1):5526
Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.
Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A
Disease models & mechanisms 2015 Apr;8(4):403-15
Disease models & mechanisms 2015 Apr;8(4):403-15
Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.
Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama TO, Kusumoto K, Zilberberg L, Sakai LY, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin DB, Nakamura T
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 19;110(8):2852-7
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 19;110(8):2852-7
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.
Hosui A, Kimura A, Yamaji D, Zhu BM, Na R, Hennighausen L
The Journal of experimental medicine 2009 Apr 13;206(4):819-31
The Journal of experimental medicine 2009 Apr 13;206(4):819-31
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