BS8559

antibody from Bioworld Technology, Inc
Targeting: CD5 LEU1, T1
Provider product page for BS8559
Western blot
Immunohistochemistry

Antibody data

Product number
BS8559 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Leu 1/CD5 polyclonal antibody
Antibody type
Polyclonal
Antigen
T-cell surface glycoprotein CD5; Lymphocyte antigen T1/Leu-1; CD5; LEU1
Description
CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CD5 protein structure - BS8559 shown in red.