Ab104445

antibody from Aladdin Scientific Corporation
Targeting: GABARAPL1 APG8L, ATG8B, ATG8L, gec1
Provider product page for Ab104445
Western blot
Immunohistochemistry

Antibody data

Product number
Ab104445 - Provider product page
Provider
Aladdin Scientific Corporation
Product name
GABARAPL1 Antibody
Antibody type
Polyclonal
Description
Rabbit anti Human GABARAPL1 Antibody, Polyclonal, could be used for WB, IHC, Flow and so on.Application:WB: 1/1000IHC: 1/100-1/500Flow: 1/10-1/50Protein FunctionUbiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.Post-translationalThe precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL1-II (By similarity). ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes. The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 1-117
Vial size
100μl,10μl,1ml,50μl
Concentration
0,5 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24months). Upon delivery aliquot. Avoid freeze/thaw cycle.
GABARAPL1 protein structure - Ab104445 shown in red.