BS7859

antibody from Bioworld Technology, Inc
Targeting: SLAMF7 19A, CD319, CRACC, CS1
Provider product page for BS7859
Western blot
Immunohistochemistry

Antibody data

Product number
BS7859 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CD319 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CD319.
Description
CS1, also known as novel Ly9, SLAMF7, CD319, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLCÎÛ and PI 3-kinase. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SLAMF7 protein structure - BS7859 shown in red.