12-2229-42

antibody from Invitrogen Antibodies
Targeting: SLAMF7 19A, CD319, CRACC, CS1
Provider product page for 12-2229-42

Antibody data

Product number
12-2229-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD319 (CRACC) Monoclonal Antibody (162), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The monoclonal antibody 162 recognizes CRACC (CD2 like receptor for activating cytotoxic cells) also known as CD319 and CS1. It is a member of the SLAM receptor family. CRACC is a 66kDa glycosylated transmembrane protein which contains a cytoplasmic ITSM domain (Immunoreceptor Tyrosine-based Switch Motif). It is this domain, found in other proteins such as CD244 and NTB-A, that interacts with SH2 containing proteins such as SAP. Interestingly the ITSM domain in CRACC is SAP independent. Instead EAT-2 acts as the signaling molecule for CRACC. This has profound impact for patients with X-linked lymphoproliferative disease (contains a SAP mutation). It should be noted that a splice variant has been reported which deletes the ITSM domain.
Conjugate
Yellow dye
Antibody clone number
162
Concentration
5 µL/Test
SLAMF7 protein structure - 12-2229-42 shown in red.