BS8577

antibody from Bioworld Technology, Inc
Targeting: GBP1
Provider product page for BS8577
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8577 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GBP1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Interferon-induced guanylate-binding protein 1; GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1; GBP1
Description
GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage step, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-ÎÛ during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi£ªs sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GBP1 protein structure - BS8577 shown in red.