Ab112361

antibody from Aladdin Scientific Corporation

Targeting: KPNA2 IPOA1, QIP2, RCH1, SRP1alpha

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab112361

Provider

Aladdin Scientific Corporation

Product name

KPNA2 Mouse mAb

Antibody type

Monoclonal

Description

Mouse anti Human KPNA2 Antibody, Monoclonal (C8), could be used for WB, IHC and so on.Application:WB: 0.01-3µg/mLIHC : 5-20µg/mL Protein FunctionFunctions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Reactivity

Human, Mouse, Porcine

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AA 157-412


Antibody clone number

C8

Vial size

100μl,10μl,1ml,20μl,50μl

Concentration

Lot by Lot

Storage

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.