BS4084

antibody from Bioworld Technology, Inc

Targeting: GSK3B

Western blot (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS4084

Provider

Bioworld Technology, Inc

Proper citation

Bioworld Technology Cat#BS4084, RRID:AB_1664070

Product name

GSK3ÉÇ (phospho S9) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic phosphopeptide derived from human GSK3ÉÇ around the phosphorylation site of Serine 9.

Description

Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer£ªs disease. Two forms of GSK-3, designated GSK-3Ï« and GSK-3ÉÇ, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer£ªs disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer£ªs disease.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.