APR00508G

antibody from Leading Biology

Targeting: CXCR1 CD181, CDw128a, CKR-1, CMKAR1, IL8RA

Western blot (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

APR00508G

Provider

Leading Biology

Product name

CXCR1 (extracellular) Antibody

Antibody type

Polyclonal

Description

Chemokine receptors belong to the seven transmembrane domain G-Protein Coupled Receptors and are differentially expressed in diverse cell types. In leukocytes, chemokines coordinate development, differentiation, anatomic distribution, trafficking, and effector functions and thereby regulate innate and adaptive immune responses.To date, 18 chemokine receptors are known and designated as CXCR1-5, CCR1-11, XCR1, and CX3CR1 based on their specific chemokine preferences. The CXC chemokine receptors specifically bind and respond to cytokines of the CXC chemokine family. CXCR1 and CXCR2 were the first chemokine receptor subtypes to be defined. They are the only known mammalian receptors for ELR+ CXC chemokines [CXC chemokines which contain the tripeptide motif glutamic acid-leucine-arginine (ELR) N-terminal to the first cysteine]. CXCR1 and CXCR2 both bind IL-8, with similar high affinity; they do not bind other types of chemokines. CXCR1 and CXCR2 are the major chemokine receptors expressed on neutrophils. They appear to operate mainly in acute inflammation and innate immunity. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the human CXCR1. Anti-CXCR1 (extracellular) antibody (#AG1298) can be used for western blot analyses and indirect flow cytometry applications. It was specifically designed to recognize human CXCR1.

Reactivity

Human

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.