CABT-B9357

antibody from Creative Diagnostics

Targeting: UTRN DMDL, DRP, DRP1

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-B9357

Provider

Creative Diagnostics

Product name

Mouse anti-Mouse Utrophin monoclonal antibody, clone 66/Vuspqijo

Antibody type

Monoclonal

Description

Utrophin is an autosomal homolog of dystrophin located on chromosome 6q24. Both encode large cytoskeletal proteins that are members of the spectrin superfamily. Spectrin family proteins are located at the cytoplasmic face and link the intracellular cytoskeleton to the extracellular matrix. Utrophin is nearly identical to dystrophin, specifically in the N-terminal actin binding domain and the C-terminus. Dystrophin is expressed primarily in the brain and muscle, while Utrophin is ubiquitously expressed. In skeletal muscle, Utrophin expression varies depending on the the state of differentiation and innervation of muscle fibers. During development, it localizes in the sarcolemma. Following formation of synaptic contacts, Utrophin is found within the postsynaptic membrane domain of the neuromuscular junction. However, its expression is not limited to postsynaptic compartments. Although dystrophin is absent in patients with Duchenne muscular dystrophy (DMD) and mdx (dystrophin deficient) mice, Utrophin is upregulated. The regulation mechanisms underlying Utrophin expression in muscle have yet to be determined.

Reactivity

Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

66/Vuspqijo

Vial size

50 _g

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.