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- Antibody Data
- Antigen structure
- References [13]
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- Validations
- Western blot [2]
- Immunohistochemistry [1]
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- Product number
- NB100-74350 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-74350, RRID:AB_1048083
- Product name
- Rabbit Polyclonal Aggrecan Neoepitope Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Aggrecan Neo (JSCNIT)
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Porcine
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at -20C. Avoid freeze-thaw cycles.
Submitted references Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses.
Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
Anti-inflammatory and anti-osteoarthritis effects of Cm-02 and Ck-02.
Activation of β-catenin in Col2-expressing chondrocytes leads to osteoarthritis-like defects in hip joint.
Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration.
Arthroprotective Effects of Cf-02 Sharing Structural Similarity with Quercetin.
Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis.
Therapeutic effects of gefitinib-encapsulated thermosensitive injectable hydrogel in intervertebral disc degeneration.
Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory.
Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix.
Lubricin protects the temporomandibular joint surfaces from degeneration.
A benzamide-linked small molecule HS-Cf inhibits TNF-α-induced interferon regulatory factor-1 in porcine chondrocytes: a potential disease-modifying drug for osteoarthritis therapeutics.
Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes.
Mitlöhner J, Kaushik R, Niekisch H, Blondiaux A, Gee CE, Happel MFK, Gundelfinger E, Dityatev A, Frischknecht R, Seidenbecher C
Cells 2020 Jan 21;9(2)
Cells 2020 Jan 21;9(2)
Smooth Muscle Cell Reprogramming in Aortic Aneurysms.
Chen PY, Qin L, Li G, Malagon-Lopez J, Wang Z, Bergaya S, Gujja S, Caulk AW, Murtada SI, Zhang X, Zhuang ZW, Rao DA, Wang G, Tobiasova Z, Jiang B, Montgomery RR, Sun L, Sun H, Fisher EA, Gulcher JR, Fernandez-Hernando C, Humphrey JD, Tellides G, Chittenden TW, Simons M
Cell stem cell 2020 Apr 2;26(4):542-557.e11
Cell stem cell 2020 Apr 2;26(4):542-557.e11
Anti-inflammatory and anti-osteoarthritis effects of Cm-02 and Ck-02.
Ho YJ, Lu JW, Ho LJ, Lai JH, Huang HS, Lee CC, Lin TY, Lien SB, Lin LC, Chen LW, Gong Z, Shen MC, Liu FC
Biochemical and biophysical research communications 2019 Sep 10;517(1):155-163
Biochemical and biophysical research communications 2019 Sep 10;517(1):155-163
Activation of β-catenin in Col2-expressing chondrocytes leads to osteoarthritis-like defects in hip joint.
Xia C, Wang P, Fang L, Ge Q, Zou Z, Dong R, Zhang P, Shi Z, Xu R, Zhang L, Luo C, Ying J, Xiao L, Shen J, Chen D, Tong P, Jin H
Journal of cellular physiology 2019 Aug;234(10):18535-18543
Journal of cellular physiology 2019 Aug;234(10):18535-18543
Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration.
Shkhyan R, Lee S, Gullo F, Li L, Peleli M, Carlstrom M, Chagin AS, Banks NW, Limfat S, Liu NQ, Evseenko D
Journal of molecular medicine (Berlin, Germany) 2018 Oct;96(10):1049-1060
Journal of molecular medicine (Berlin, Germany) 2018 Oct;96(10):1049-1060
Arthroprotective Effects of Cf-02 Sharing Structural Similarity with Quercetin.
Liu FC, Lu JW, Chien CY, Huang HS, Lee CC, Lien SB, Lin LC, Chen LW, Ho YJ, Shen MC, Ho LJ, Lai JH
International journal of molecular sciences 2018 May 14;19(5)
International journal of molecular sciences 2018 May 14;19(5)
Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis.
Song J, Baek IJ, Chun CH, Jin EJ
Nature communications 2018 Aug 24;9(1):3427
Nature communications 2018 Aug 24;9(1):3427
Therapeutic effects of gefitinib-encapsulated thermosensitive injectable hydrogel in intervertebral disc degeneration.
Pan Z, Sun H, Xie B, Xia D, Zhang X, Yu D, Li J, Xu Y, Wang Z, Wu Y, Zhang X, Wang Y, Fu Q, Hu W, Yang Y, Bunpetch V, Shen W, Heng BC, Zhang S, Ouyang H
Biomaterials 2018 Apr;160:56-68
Biomaterials 2018 Apr;160:56-68
Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory.
Lai JH, Luo SF, Hung LF, Huang CY, Lien SB, Lin LC, Liu FC, Yen BL, Ho LJ
Scientific reports 2017 May 24;7(1):2359
Scientific reports 2017 May 24;7(1):2359
Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix.
Wang Y, Yu D, Liu Z, Zhou F, Dai J, Wu B, Zhou J, Heng BC, Zou XH, Ouyang H, Liu H
Stem cell research & therapy 2017 Aug 14;8(1):189
Stem cell research & therapy 2017 Aug 14;8(1):189
Lubricin protects the temporomandibular joint surfaces from degeneration.
Hill A, Duran J, Purcell P
PloS one 2014;9(9):e106497
PloS one 2014;9(9):e106497
A benzamide-linked small molecule HS-Cf inhibits TNF-α-induced interferon regulatory factor-1 in porcine chondrocytes: a potential disease-modifying drug for osteoarthritis therapeutics.
Liu FC, Huang HS, Huang CY, Yang R, Chang DM, Lai JH, Ho LJ
Journal of clinical immunology 2011 Dec;31(6):1131-42
Journal of clinical immunology 2011 Dec;31(6):1131-42
Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes.
Huang CY, Lai KY, Hung LF, Wu WL, Liu FC, Ho LJ
Rheumatology (Oxford, England) 2011 Aug;50(8):1379-89
Rheumatology (Oxford, England) 2011 Aug;50(8):1379-89
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Aggrecan Neoepitope Antibody [NB100-74350] - Analysis of ACAN in L929 whole cell extract using NB100-74350.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Aggrecan Neoepitope Antibody [NB100-74350] - Analysis of ACAN in U2OS cell lysate.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: Aggrecan Neoepitope Antibody [NB100-74350] - Analysis of ACAN in mouse cartilage with hematoxylin counterstain.
