251591

antibody from Abbiotec

Targeting: ACAN AGC1, CSPG1, CSPGCP, MSK16

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

251591

Provider

Abbiotec

Proper citation

Abbiotec Cat#251591, RRID:AB_10634847

Product name

Aggrecan Antibody

Antibody type

Polyclonal

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human aggrecan.

Description

Aggrecan core protein (Cartilage-specific proteoglycan core protein) is a major component of extracellular matrix of cartilagenous tissues. The major function of aggrecan is to resist compression in cartilage. Aggrecan binds avidly to hyaluronic acid via an N-terminal globular region. Expression of aggrecan is restricited to cartilages in chondrocytes throughout the developing skeleton. Aggrecan contains mostly chondroitin sulfate and lesser keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. Defects in aggrecan are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) and spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN).

Reactivity

Human, Mouse, Rat, Bovine, Chicken/Avian, Porcine, Rabbit

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Storage

Store at -20C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.