Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 15083-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15083-1-AP, RRID:AB_2082207
- Product name
- COQ7 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated COQ7 antibody (Cat. #15083-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Human COQ4 deficiency: delineating the clinical, metabolic and neuroimaging phenotypes.
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.
Cold-inducible RNA binding protein agonist enhances the cardioprotective effect of UW solution during extended heart preservation.
Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet.
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice.
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
Detection of 6-demethoxyubiquinone in CoQ10 deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.
Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death.
4-Hydroxybenzoic acid restores CoQ10 biosynthesis in human COQ2 deficiency.
Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.
Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9.
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption.
Laugwitz L, Seibt A, Herebian D, Peralta S, Kienzle I, Buchert R, Falb R, Gauck D, Müller A, Grimmel M, Beck-Woedel S, Kern J, Daliri K, Katibeh P, Danhauser K, Leiz S, Alesi V, Baertling F, Vasco G, Steinfeld R, Wagner M, Caglayan AO, Gumus H, Burmeister M, Mayatepek E, Martinelli D, Tamhankar PM, Tamhankar V, Joset P, Steindl K, Rauch A, Bonnen PE, Froukh T, Groeschel S, Krägeloh-Mann I, Haack TB, Distelmaier F
Journal of medical genetics 2021 Oct 16;
Journal of medical genetics 2021 Oct 16;
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.
Yan PJ, Ren ZX, Shi ZF, Wan CL, Han CJ, Zhu LS, Li NN, Waddington JL, Zhen XC
Acta pharmacologica Sinica 2021 Nov 22;
Acta pharmacologica Sinica 2021 Nov 22;
Cold-inducible RNA binding protein agonist enhances the cardioprotective effect of UW solution during extended heart preservation.
Pan HZ, Zhang LJ, Liu YW, Li YN, Su ZH, Meng J, Zhang H
Artificial organs 2020 Oct;44(10):E406-E418
Artificial organs 2020 Oct;44(10):E406-E418
Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet.
Meza-Torres C, Hernández-Camacho JD, Cortés-Rodríguez AB, Fang L, Bui Thanh T, Rodríguez-Bies E, Navas P, López-Lluch G
Antioxidants (Basel, Switzerland) 2020 May 15;9(5)
Antioxidants (Basel, Switzerland) 2020 May 15;9(5)
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Zhang Z, Zong C, Jiang M, Hu H, Cheng X, Ni J, Yi X, Jiang B, Tian F, Chang MW, Su W, Zhu L, Li J, Xiang X, Miao C, Gorospe M, de Cabo R, Dou Y, Ju Z, Yang J, Jiang C, Yang Z, Wang W
Nature communications 2020 Jun 16;11(1):3067
Nature communications 2020 Jun 16;11(1):3067
β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice.
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC
EMBO molecular medicine 2019 Jan;11(1)
EMBO molecular medicine 2019 Jan;11(1)
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC
Scientific reports 2018 Sep 18;8(1):14013
Scientific reports 2018 Sep 18;8(1):14013
Detection of 6-demethoxyubiquinone in CoQ10 deficiency disorders: Insights into enzyme interactions and identification of potential therapeutics.
Herebian D, Seibt A, Smits SHJ, Bünning G, Freyer C, Prokisch H, Karall D, Wredenberg A, Wedell A, López LC, Mayatepek E, Distelmaier F
Molecular genetics and metabolism 2017 Jul;121(3):216-223
Molecular genetics and metabolism 2017 Jul;121(3):216-223
Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death.
Yan Q, Han C, Wang G, Waddington JL, Zheng L, Zhen X
Molecular pharmacology 2017 Dec;92(6):640-652
Molecular pharmacology 2017 Dec;92(6):640-652
4-Hydroxybenzoic acid restores CoQ10 biosynthesis in human COQ2 deficiency.
Herebian D, Seibt A, Smits SHJ, Rodenburg RJ, Mayatepek E, Distelmaier F
Annals of clinical and translational neurology 2017 Dec;4(12):902-908
Annals of clinical and translational neurology 2017 Dec;4(12):902-908
Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance.
Zhang L, Yang H, Zhang W, Liang Z, Huang Q, Xu G, Zhen X, Zheng LT
Journal of neurochemistry 2017 Aug;142(4):574-588
Journal of neurochemistry 2017 Aug;142(4):574-588
Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9.
Danhauser K, Herebian D, Haack TB, Rodenburg RJ, Strom TM, Meitinger T, Klee D, Mayatepek E, Prokisch H, Distelmaier F
European journal of human genetics : EJHG 2016 Mar;24(3):450-4
European journal of human genetics : EJHG 2016 Mar;24(3):450-4
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
Monaghan RM, Barnes RG, Fisher K, Andreou T, Rooney N, Poulin GB, Whitmarsh AJ
Nature cell biology 2015 Jun;17(6):782-92
Nature cell biology 2015 Jun;17(6):782-92
ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption.
Ashraf S, Gee HY, Woerner S, Xie LX, Vega-Warner V, Lovric S, Fang H, Song X, Cattran DC, Avila-Casado C, Paterson AD, Nitschké P, Bole-Feysot C, Cochat P, Esteve-Rudd J, Haberberger B, Allen SJ, Zhou W, Airik R, Otto EA, Barua M, Al-Hamed MH, Kari JA, Evans J, Bierzynska A, Saleem MA, Böckenhauer D, Kleta R, El Desoky S, Hacihamdioglu DO, Gok F, Washburn J, Wiggins RC, Choi M, Lifton RP, Levy S, Han Z, Salviati L, Prokisch H, Williams DS, Pollak M, Clarke CF, Pei Y, Antignac C, Hildebrandt F
The Journal of clinical investigation 2013 Dec;123(12):5179-89
The Journal of clinical investigation 2013 Dec;123(12):5179-89
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 15083-1-AP(COQ7 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 15083-1-AP(COQ7 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The COQ7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COQ7. This antibody recognizes human,mouse,rat antigen. The COQ7 antibody has been validated for the following applications: ELISA, WB, IHC analysis.