12780-1-AP

antibody from Proteintech Group

Targeting: CCP110 CP110, KIAA0419

Provider product page for 12780-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [105]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [2]
Immunohistochemistry [1]

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Product number: 12780-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12780-1-AP, RRID:AB_10638480
Product name: CP110 antibody
Antibody type: Polyclonal
Description: KD/KO validated CP110 antibody (Cat. #12780-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, Canine and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat, Canine
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CCP110 protein structure - 12780-1-AP shown in red.

Submitted references LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.

Shen XL, Yuan JF, Qin XH, Song GP, Hu HB, Tu HQ, Song ZQ, Li PY, Xu YL, Li S, Jian XX, Li JN, He CY, Yu XP, Liang LY, Wu M, Han QY, Wang K, Li AL, Zhou T, Zhang YC, Wang N, Li HY
The Journal of cell biology 2022 Jan 3;221(1)

Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.

Bernatik O, Paclikova P, Kotrbova A, Bryja V, Cajanek L
Frontiers in cell and developmental biology 2021;9:623753

Analyzing Centrioles and Cilia by Expansion Microscopy.

Kong D, Loncarek J
Methods in molecular biology (Clifton, N.J.) 2021;2329:249-263

Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase.

Shao X, Ding Z, Zhou W, Li Y, Li Z, Cui H, Lin X, Cao G, Cheng B, Sun H, Li M, Liu K, Lu D, Geng S, Shi W, Zhang G, Song Q, Chen L, Wang G, Su W, Cai L, Fang L, Leong DT, Li Y, Yu XF, Li H
Nature nanotechnology 2021 Oct;16(10):1150-1160

Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold.

Schweizer N, Haren L, Dutto I, Viais R, Lacasa C, Merdes A, Lüders J
Nature communications 2021 Oct 15;12(1):6042

The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis.

Stemm-Wolf AJ, O'Toole ET, Sheridan RM, Morgan JT, Pearson CG
Molecular biology of the cell 2021 Oct 1;32(20):ar4

NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.

Liu M, Zhang W, Li M, Feng J, Kuang W, Chen X, Yang F, Sun Q, Xu Z, Hua J, Yang C, Liu W, Shu Q, Yang Y, Zhou T, Xie S
Cell research 2021 Nov;31(11):1199-1211

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.

Dhekne HS, Yanatori I, Vides EG, Sobu Y, Diez F, Tonelli F, Pfeffer SR
Life science alliance 2021 May;4(5)

Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.

Sobu Y, Wawro PS, Dhekne HS, Yeshaw WM, Pfeffer SR
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 9;118(10)

Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle.

Ito KK, Watanabe K, Ishida H, Matsuhashi K, Chinen T, Hata S, Kitagawa D
The Journal of cell biology 2021 Mar 1;220(3)

Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells.

Qatato M, Venugopalan V, Al-Hashimi A, Rehders M, Valentine AD, Hein Z, Dallto U, Springer S, Brix K
Cells 2021 Jun 16;10(6)

CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.

Gonçalves AB, Hasselbalch SK, Joensen BB, Patzke S, Martens P, Ohlsen SK, Quinodoz M, Nikopoulos K, Suleiman R, Damsø Jeppesen MP, Weiss C, Christensen ST, Rivolta C, Andersen JS, Farinelli P, Pedersen LB
eLife 2021 Jul 14;10

Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.

Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK
Current biology : CB 2021 Jul 12;31(13):2895-2905.e7

TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.

Balestra FR, Domínguez-Calvo A, Wolf B, Busso C, Buff A, Averink T, Lipsanen-Nyman M, Huertas P, Ríos RM, Gönczy P
eLife 2021 Jan 25;10

EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis.

Partisani M, Baron CL, Ghossoub R, Fayad R, Pagnotta S, Abélanet S, Macia E, Brau F, Lacas-Gervais S, Benmerah A, Luton F, Franco M
Journal of cell science 2021 Jan 22;134(2)

RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.

Jewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris R
Developmental cell 2021 Feb 8;56(3):325-340.e8

Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.

Chinen T, Yamazaki K, Hashimoto K, Fujii K, Watanabe K, Takeda Y, Yamamoto S, Nozaki Y, Tsuchiya Y, Takao D, Kitagawa D
The Journal of cell biology 2021 Feb 1;220(2)

Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.

Arslanhan MD, Rauniyar N, Yates JR 3rd, Firat-Karalar EN
EMBO reports 2021 Aug 4;22(8):e51902

The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels.

Porter AP, Reed H, White GRM, Ogg EL, Whalley HJ, Malliri A
Journal of cell science 2021 Apr 1;134(7)

WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.

Steib E, Laporte MH, Gambarotto D, Olieric N, Zheng C, Borgers S, Olieric V, Le Guennec M, Koll F, Tassin AM, Steinmetz MO, Guichard P, Hamel V
eLife 2020 Sep 18;9

Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesis.

Fan JR, You LR, Wang WJ, Huang WS, Chu CT, Chi YH, Chen HC
EMBO reports 2020 Oct 5;21(10):e49680

The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression.

Takeda Y, Yamazaki K, Hashimoto K, Watanabe K, Chinen T, Kitagawa D
Journal of cell science 2020 Oct 1;133(19)

Growth disadvantage associated with centrosome amplification drives population-level centriole number homeostasis.

Sala R, Farrell KC, Stearns T
Molecular biology of the cell 2020 Nov 15;31(24):2646-2656

LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome.

Bozal-Basterra L, Gonzalez-Santamarta M, Muratore V, Bermejo-Arteagabeitia A, Da Fonseca C, Barroso-Gomila O, Azkargorta M, Iloro I, Pampliega O, Andrade R, Martín-Martín N, Branon TC, Ting AY, Rodríguez JA, Carracedo A, Elortza F, Sutherland JD, Barrio R
eLife 2020 Jun 18;9

Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.

Bangs FK, Miller P, O'Neill E
Disease models & mechanisms 2020 Jul 30;13(7)

Cep57 and Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole biogenesis.

Zhao H, Yang S, Chen Q, Duan X, Li G, Huang Q, Zhu X, Yan X
Journal of cell science 2020 Jul 3;133(13)

ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.

Jung E, Choi TI, Lee JE, Kim CH, Kim J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1331-1344

NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells.

Chinen T, Yamamoto S, Takeda Y, Watanabe K, Kuroki K, Hashimoto K, Takao D, Kitagawa D
The EMBO journal 2020 Jan 15;39(2):e102378

Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.

Flynn M, Whitton L, Donohoe G, Morrison CG, Morris DW
Human molecular genetics 2020 Feb 1;29(3):407-417

PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.

Sladky VC, Knapp K, Szabo TG, Braun VZ, Bongiovanni L, van den Bos H, Spierings DC, Westendorp B, Curinha A, Stojakovic T, Scharnagl H, Timelthaler G, Tsuchia K, Pinter M, Semmler G, Foijer F, de Bruin A, Reiberger T, Rohr-Udilova N, Villunger A
EMBO reports 2020 Dec 3;21(12):e50893

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.

Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K
eLife 2020 Aug 6;9

Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila.

Dobbelaere J, Schmidt Cernohorska M, Huranova M, Slade D, Dammermann A
Current biology : CB 2020 Aug 3;30(15):3045-3056.e7

Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5.

Kodani A, Kenny C, Lai A, Gonzalez DM, Stronge E, Sejourne GM, Isacco L, Partlow JN, O'Donnell A, McWalter K, Byrne AB, Barkovich AJ, Yang E, Hill RS, Gawlinski P, Wiszniewski W, Cohen JS, Fatemi SA, Baranano KW, Sahin M, Vossler DG, Yuskaitis CJ, Walsh CA
Neuron 2020 Apr 22;106(2):246-255.e6

Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1.

Mao H, Tang Z, Li H, Sun B, Tan M, Fan S, Zhu Y, Sun Y
Protein & cell 2019 Oct;10(10):726-744

Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.

Lo CH, Lin IH, Yang TT, Huang YC, Tanos BE, Chou PC, Chang CW, Tsay YG, Liao JC, Wang WJ
The Journal of cell biology 2019 Oct 7;218(10):3489-3505

Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.

Khouj EM, Prosser SL, Tada H, Chong WM, Liao JC, Sugasawa K, Morrison CG
Journal of cell science 2019 Oct 3;132(19)

MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.

Xie S, Farmer T, Naslavsky N, Caplan S
Journal of cell science 2019 Nov 14;132(22)

Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.

Odabasi E, Gul S, Kavakli IH, Firat-Karalar EN
EMBO reports 2019 Jun;20(6)

A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.

So C, Seres KB, Steyer AM, Mönnich E, Clift D, Pejkovska A, Möbius W, Schuh M
Science (New York, N.Y.) 2019 Jun 28;364(6447)

Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells.

Wolf B, Busso C, Gönczy P
Nature communications 2019 Jun 28;10(1):2859

Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.

Clijsters L, Hoencamp C, Calis JJA, Marzio A, Handgraaf SM, Cuitino MC, Rosenberg BR, Leone G, Pagano M
Molecular cell 2019 Jun 20;74(6):1264-1277.e7

HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates.

Yoshiba S, Tsuchiya Y, Ohta M, Gupta A, Shiratsuchi G, Nozaki Y, Ashikawa T, Fujiwara T, Natsume T, Kanemaki MT, Kitagawa D
Journal of cell science 2019 Jun 20;132(12)

Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.

Walia V, Cuenca A, Vetter M, Insinna C, Perera S, Lu Q, Ritt DA, Semler E, Specht S, Stauffer J, Morrison DK, Lorentzen E, Westlake CJ
Developmental cell 2019 Jul 22;50(2):229-246.e7

Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.

Insinna C, Lu Q, Teixeira I, Harned A, Semler EM, Stauffer J, Magidson V, Tiwari A, Kenworthy AK, Narayan K, Westlake CJ
Nature communications 2019 Jan 25;10(1):428

The Cep57-pericentrin module organizes PCM expansion and centriole engagement.

Watanabe K, Takao D, Ito KK, Takahashi M, Kitagawa D
Nature communications 2019 Feb 25;10(1):931

NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.

Li M, Xu X, Zhang J, Liu M, Wang W, Gao Y, Sun Q, Zhang J, Lu Y, Wang F, Liu W, Zhou T, Yang Y
Cell death & disease 2019 Aug 19;10(9):628

A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling.

Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S
Cell reports 2019 Aug 13;28(7):1907-1922.e6

Self-organization of Plk4 regulates symmetry breaking in centriole duplication.

Yamamoto S, Kitagawa D
Nature communications 2019 Apr 18;10(1):1810

CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis.

Tsai JJ, Hsu WB, Liu JH, Chang CW, Tang TK
Scientific reports 2019 Apr 15;9(1):6037

Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow-Resident Melanoma CTCs.

Vishnoi M, Boral D, Liu H, Sprouse ML, Yin W, Goswami-Sewell D, Tetzlaff MT, Davies MA, Oliva ICG, Marchetti D
Cancer research 2018 Sep 15;78(18):5349-5362

M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.

Huang N, Zhang D, Li F, Chai P, Wang S, Teng J, Chen J
Nature communications 2018 Oct 30;9(1):4511

The dual role of the centrosome in organizing the microtubule network in interphase.

Gavilan MP, Gandolfo P, Balestra FR, Arias F, Bornens M, Rios RM
EMBO reports 2018 Nov;19(11)

PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion.

Fong CS, Ozaki K, Tsou MB
Molecular biology of the cell 2018 Nov 15;29(23):2801-2808

Aberrant epithelial remodeling with impairment of cilia architecture in non-cystic fibrosis bronchiectasis.

Chen ZG, Li YY, Wang ZN, Li M, Lim HF, Zhou YQ, Cai LM, Li YT, Yang LF, Zhang TT, Wang DY
Journal of thoracic disease 2018 Mar;10(3):1753-1764

Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.

Weng RR, Yang TT, Huang CE, Chang CW, Wang WJ, Liao JC
Biophysical journal 2018 Jul 17;115(2):263-275

The small GTPase RSG1 controls a final step in primary cilia initiation.

Agbu SO, Liang Y, Liu A, Anderson KV
The Journal of cell biology 2018 Jan 2;217(1):413-427

Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.

Lee SH, Joo K, Jung EJ, Hong H, Seo J, Kim J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Feb;32(2):957-968

VPS4 is a dynamic component of the centrosome that regulates centrosome localization of γ-tubulin, centriolar satellite stability and ciliogenesis.

Ott C, Nachmias D, Adar S, Jarnik M, Sherman S, Birnbaum RY, Lippincott-Schwartz J, Elia N
Scientific reports 2018 Feb 20;8(1):3353

Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.

Bozal-Basterra L, Martín-Ruíz I, Pirone L, Liang Y, Sigurðsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodríguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD, Barrio R
American journal of human genetics 2018 Feb 1;102(2):249-265

Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication.

Ling H, Peng L, Wang J, Rahhal R, Seto E
Cell reports 2018 Dec 4;25(10):2851-2865.e3

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.

Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY
Nature communications 2018 Dec 11;9(1):5277

PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN.

Sydor AM, Coyaud E, Rovelli C, Laurent E, Liu H, Raught B, Mennella V
eLife 2018 Aug 31;7

Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.

Barny I, Perrault I, Michel C, Soussan M, Goudin N, Rio M, Thomas S, Attié-Bitach T, Hamel C, Dollfus H, Kaplan J, Rozet JM, Gerard X
Human molecular genetics 2018 Aug 1;27(15):2689-2702

Centrobin controls primary ciliogenesis in vertebrates.

Ogungbenro YA, Tena TC, Gaboriau D, Lalor P, Dockery P, Philipp M, Morrison CG
The Journal of cell biology 2018 Apr 2;217(4):1205-1215

Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.

Wang JT, Kong D, Hoerner CR, Loncarek J, Stearns T
eLife 2017 Sep 14;6

The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome.

Loukil A, Tormanen K, Sütterlin C
The Journal of cell biology 2017 May 1;216(5):1287-1300

USP9X regulates centrosome duplication and promotes breast carcinogenesis.

Li X, Song N, Liu L, Liu X, Ding X, Song X, Yang S, Shan L, Zhou X, Su D, Wang Y, Zhang Q, Cao C, Ma S, Yu N, Yang F, Wang Y, Yao Z, Shang Y, Shi L
Nature communications 2017 Mar 31;8:14866

Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning.

Wolf B, Diop F, Ferraris P, Wichit S, Busso C, Missé D, Gönczy P
Open biology 2017 Jan;7(1)

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer.

Cosenza MR, Cazzola A, Rossberg A, Schieber NL, Konotop G, Bausch E, Slynko A, Holland-Letz T, Raab MS, Dubash T, Glimm H, Poppelreuther S, Herold-Mende C, Schwab Y, Krämer A
Cell reports 2017 Aug 22;20(8):1906-1920

Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.

Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, Busso C, Olieric N, Sorzano COS, Steinmetz MO, Guichard P, Gönczy P
Current biology : CB 2017 Aug 21;27(16):2486-2498.e6

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.

Chen HY, Wu CT, Tang CC, Lin YN, Wang WJ, Tang TK
Nature communications 2017 Aug 15;8(1):247

Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein.

Zhao X, Jin M, Wang M, Sun L, Hong X, Cao Y, Wang C
Cell cycle (Georgetown, Tex.) 2016 Sep;15(17):2367-75

Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis.

Walentek P, Quigley IK, Sun DI, Sajjan UK, Kintner C, Harland RM
eLife 2016 Sep 13;5

A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.

Nechipurenko IV, Olivier-Mason A, Kazatskaya A, Kennedy J, McLachlan IG, Heiman MG, Blacque OE, Sengupta P
Developmental cell 2016 Sep 12;38(5):493-506

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.

Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier JM, Ye T, Chavant V, Joint M, Esashi F, Dejaegere A, Gönczy P, Tora L
Nature communications 2016 Oct 31;7:13227

Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.

Yadav SP, Sharma NK, Liu C, Dong L, Li T, Swaroop A
Development (Cambridge, England) 2016 May 1;143(9):1491-501

MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.

Lee SH, Lee MS, Choi TI, Hong H, Seo JY, Kim CH, Kim J
Scientific reports 2016 Jun 6;6:27284

CEP295 interacts with microtubules and is required for centriole elongation.

Chang CW, Hsu WB, Tsai JJ, Tang CJ, Tang TK
Journal of cell science 2016 Jul 1;129(13):2501-13

Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.

Tsuchiya Y, Yoshiba S, Gupta A, Watanabe K, Kitagawa D
Nature communications 2016 Aug 26;7:12567

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.

Hilbert M, Noga A, Frey D, Hamel V, Guichard P, Kraatz SH, Pfreundschuh M, Hosner S, Flückiger I, Jaussi R, Wieser MM, Thieltges KM, Deupi X, Müller DJ, Kammerer RA, Gönczy P, Hirono M, Steinmetz MO
Nature cell biology 2016 Apr;18(4):393-403

Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function.

Cortés CR, McInerney-Leo AM, Vogel I, Rondón Galeano MC, Leo PJ, Harris JE, Anderson LK, Keith PA, Brown MA, Ramsing M, Duncan EL, Zankl A, Wicking C
Scientific reports 2016 Apr 20;6:24083

MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition.

Zhang Y, Wang Y, Wei Y, Li M, Yu S, Ye M, Zhang H, Chen S, Liu W, Zhang J
Scientific reports 2015 Oct 21;5:15424

Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.

Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E
Molecular cancer therapeutics 2015 Nov;14(11):2576-85

The Tumor Suppressor Cdkn3 Is Required for Maintaining the Proper Number of Centrosomes by Regulating the Centrosomal Stability of Mps1.

Srinivas V, Kitagawa M, Wong J, Liao PJ, Lee SH
Cell reports 2015 Nov 24;13(8):1569-77

Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.

Hong H, Kim J, Kim J
Biochemical and biophysical research communications 2015 May 22;461(1):180-5

Centrin2 regulates CP110 removal in primary cilium formation.

Prosser SL, Morrison CG
The Journal of cell biology 2015 Mar 16;208(6):693-701

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.

Pagan JK, Marzio A, Jones MJ, Saraf A, Jallepalli PV, Florens L, Washburn MP, Pagano M
Nature cell biology 2015 Jan;17(1):31-43

Lineage specificity of primary cilia in the mouse embryo.

Bangs FK, Schrode N, Hadjantonakis AK, Anderson KV
Nature cell biology 2015 Feb;17(2):113-22

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.

Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, Yamamoto T, Dynlacht BD, Matsuura S
Cell reports 2015 Feb 10;10(5):664-673

Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.

Stinchcombe JC, Randzavola LO, Angus KL, Mantell JM, Verkade P, Griffiths GM
Current biology : CB 2015 Dec 21;25(24):3239-44

Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.

Ran J, Yang Y, Li D, Liu M, Zhou J
Scientific reports 2015 Aug 6;5:12917

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.

Kodani A, Yu TW, Johnson JR, Jayaraman D, Johnson TL, Al-Gazali L, Sztriha L, Partlow JN, Kim H, Krup AL, Dammermann A, Krogan NJ, Walsh CA, Reiter JF
eLife 2015 Aug 22;4

CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.

Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R, Sun SC, Zhou J
Cell research 2014 Nov;24(11):1342-53

The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis.

Kim M, Kim M, Lee MS, Kim CH, Lim DS
Nature communications 2014 Nov 4;5:5370

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells.

Keller D, Orpinell M, Olivier N, Wachsmuth M, Mahen R, Wyss R, Hachet V, Ellenberg J, Manley S, Gönczy P
The Journal of cell biology 2014 Mar 3;204(5):697-712

PIPKIγ targets to the centrosome and restrains centriole duplication.

Xu Q, Zhang Y, Xiong X, Huang Y, Salisbury JL, Hu J, Ling K
Journal of cell science 2014 Mar 15;127(Pt 6):1293-305

SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication.

Fong CS, Kim M, Yang TT, Liao JC, Tsou MF
Developmental cell 2014 Jul 28;30(2):238-45

C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.

Ye X, Zeng H, Ning G, Reiter JF, Liu A
Proceedings of the National Academy of Sciences of the United States of America 2014 Feb 11;111(6):2164-9

Stabilization of cartwheel-less centrioles for duplication requires CEP295-mediated centriole-to-centrosome conversion.

Izquierdo D, Wang WJ, Uryu K, Tsou MF
Cell reports 2014 Aug 21;8(4):957-65

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.

Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD
Nature 2013 Mar 14;495(7440):255-9

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.

Wang WJ, Tay HG, Soni R, Perumal GS, Goll MG, Macaluso FP, Asara JM, Amack JD, Tsou MF
Nature cell biology 2013 Jun;15(6):591-601

Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.

Kodani A, Salomé Sirerol-Piquer M, Seol A, Garcia-Verdugo JM, Reiter JF
The EMBO journal 2013 Feb 20;32(4):597-607

The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.

Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X, Zhu X
Nature cell biology 2013 Dec;15(12):1434-44

CCDC41 is required for ciliary vesicle docking to the mother centriole.

Joo K, Kim CG, Lee MS, Moon HY, Lee SH, Kim MJ, Kweon HS, Park WY, Kim CH, Gleeson JG, Kim J
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):5987-92

miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.

Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, Li Y, Yan X, Zhu X
Nature cell biology 2012 Jun 10;14(7):697-706

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 12780-1-AP(CP110 antibody) at dilution of 1:400
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-CP110 (IP:12780-1-AP, 3ug; Detection:12780-1-AP 1:1000) with HeLa cells lysate 3000ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP result of CP110(12780-1-AP) by Dr. Corbit, Kevin.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 12780-1-AP(CP110 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue