DPABH-05774

antibody from Creative Diagnostics

Targeting: RPA2

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DPABH-05774

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-05774, RRID:AB_2509460

Product name

Goat Anti-Human RPA2 Polyclonal Antibody

Antibody type

Polyclonal

Description

This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways

Reactivity

Human

Host

Goat

Conjugate

Unconjugated

Isotype

IgG

Concentration

Lot specific

Storage

2 - 8° C. 1 year from date of receipt