CABT-B8833

antibody from Creative Diagnostics

Targeting: IDUA MPS1, MPSI

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-B8833

Provider

Creative Diagnostics

Product name

Anti-IDUA monoclonal antibody, clone 563720

Antibody type

Monoclonal

Description

alpha -L-Iduronidase encoded by the IDUA gene is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGs). It hydrolyzes the non?reducing terminal alpha -L-iduronic acid residues in GAGs including dermatan sulfate and heparan sulfate. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). MPS I causes progressive cellular, tissue and organ damage, and several clinical studies using enzyme replacement therapy have shown promising benefits. The sequence of human IDUA shares 79% amino acid identity with mouse IDUA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

563720

Vial size

100ug

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution.6 months, -20 to -70°C under sterile conditions after reconstit