Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 22787-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#22787-1-AP, RRID:AB_11182479
- Product name
- MCT4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MCT4 antibody (Cat. #22787-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Combination of Exercise and Intake of Amino Acid Mixture Synergistically Induces Beige Adipocyte Formation in Mice.
Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells.
Activation of Hippocampal IR/IRS-1 Signaling Contributes to the Treatment with Zuogui Jiangtang Jieyu Decoction on the Diabetes-Related Depression.
Comprehensive Analysis of the Relationship Between Metabolic Reprogramming and Immune Function in Prostate Cancer.
Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System.
Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis.
Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis.
In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3.
Lactate sensing mechanisms in arterial chemoreceptor cells.
Overexpression of monocarboxylate transporter 4 promotes the migration and invasion of non-carcinogenic L929 fibroblast cells.
Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma.
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.
Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts.
Jet-Lagged Nanoparticles Enhanced Immunotherapy Efficiency through Synergistic Reconstruction of Tumor Microenvironment and Normalized Tumor Vasculature.
Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer.
Acidic Stress Triggers Sodium-Coupled Bicarbonate Transport and Promotes Survival in A375 Human Melanoma Cells.
Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4).
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
Prognostic value of monocarboxylate transporter 4 in patients with esophageal squamous cell carcinoma.
Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device.
Kojima T, Esaki N, Tsuda T
Journal of nutritional science and vitaminology 2021;67(4):225-233
Journal of nutritional science and vitaminology 2021;67(4):225-233
Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells.
Nadai T, Narumi K, Furugen A, Saito Y, Iseki K, Kobayashi M
Biological & pharmaceutical bulletin 2021;44(9):1247-1253
Biological & pharmaceutical bulletin 2021;44(9):1247-1253
Activation of Hippocampal IR/IRS-1 Signaling Contributes to the Treatment with Zuogui Jiangtang Jieyu Decoction on the Diabetes-Related Depression.
Yang H, Ling J, Meng P, Liu J, Lin X, Li W, Wang Y
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6688723
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6688723
Comprehensive Analysis of the Relationship Between Metabolic Reprogramming and Immune Function in Prostate Cancer.
Xie W, Guo H, Zhang J, Hu L, Wu Y, Wang X
OncoTargets and therapy 2021;14:3251-3266
OncoTargets and therapy 2021;14:3251-3266
Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System.
Hu J, Cai M, Shang Q, Li Z, Feng Y, Liu B, Xue X, Lou S
Frontiers in physiology 2021;12:629914
Frontiers in physiology 2021;12:629914
Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis.
Tao Y, Shao F, Cai M, Liu Z, Peng Y, Huang Q, Meng F
Frontiers in oncology 2021;11:714598
Frontiers in oncology 2021;11:714598
Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis.
Ryuge A, Kosugi T, Maeda K, Banno R, Gou Y, Zaitsu K, Ito T, Sato Y, Hirayama A, Tsubota S, Honda T, Nakajima K, Ozaki T, Kondoh K, Takahashi K, Kato N, Ishimoto T, Soga T, Nakagawa T, Koike T, Arima H, Yuzawa Y, Minokoshi Y, Maruyama S, Kadomatsu K
JCI insight 2021 Oct 22;6(20)
JCI insight 2021 Oct 22;6(20)
In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3.
Abdali A, Baci D, Damiani I, Belloni F, De Dominicis C, Gelmi ML, Corsini A, Bellosta S
Pharmacological research 2021 Jun;168:105592
Pharmacological research 2021 Jun;168:105592
Lactate sensing mechanisms in arterial chemoreceptor cells.
Torres-Torrelo H, Ortega-Sáenz P, Gao L, López-Barneo J
Nature communications 2021 Jul 6;12(1):4166
Nature communications 2021 Jul 6;12(1):4166
Overexpression of monocarboxylate transporter 4 promotes the migration and invasion of non-carcinogenic L929 fibroblast cells.
Li X, Zhou X, Liu Y, Fan J, Huo H, Yao J, Wang L, Ma N
Oncology letters 2021 Jan;21(1):44
Oncology letters 2021 Jan;21(1):44
Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma.
Feng Q, Yao Q, Li B, Xie Y, Zhang H, Xu Z, Lu K, Hu K, Cheng Y, Shi B, Huang C, Li L, Wu X, You S, Shi J, Zhu W
Journal of Cancer 2020;11(16):4907-4916
Journal of Cancer 2020;11(16):4907-4916
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y
Theranostics 2020;10(26):12044-12059
Theranostics 2020;10(26):12044-12059
Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.
Yamaguchi A, Narumi K, Furugen A, Iseki K, Kobayashi M
Biochemical and biophysical research communications 2020 Sep 3;529(4):1061-1065
Biochemical and biophysical research communications 2020 Sep 3;529(4):1061-1065
Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts.
Zhang Z, Gao Z, Rajthala S, Sapkota D, Dongre H, Parajuli H, Suliman S, Das R, Li L, Bindoff LA, Costea DE, Liang X
Cellular and molecular life sciences : CMLS 2020 Mar;77(6):1115-1133
Cellular and molecular life sciences : CMLS 2020 Mar;77(6):1115-1133
Jet-Lagged Nanoparticles Enhanced Immunotherapy Efficiency through Synergistic Reconstruction of Tumor Microenvironment and Normalized Tumor Vasculature.
Jiang Z, Xiong H, Yang S, Lu Y, Deng Y, Yao J, Yao J
Advanced healthcare materials 2020 Jun;9(12):e2000075
Advanced healthcare materials 2020 Jun;9(12):e2000075
Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer.
Pan Y, Zheng Q, Ni W, Wei Z, Yu S, Jia Q, Wang M, Wang A, Chen W, Lu Y
Frontiers in pharmacology 2019;10:590
Frontiers in pharmacology 2019;10:590
Acidic Stress Triggers Sodium-Coupled Bicarbonate Transport and Promotes Survival in A375 Human Melanoma Cells.
Yang OCY, Loh SH
Scientific reports 2019 May 2;9(1):6858
Scientific reports 2019 May 2;9(1):6858
Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4).
Futagi Y, Kobayashi M, Narumi K, Furugen A, Iseki K
Cellular and molecular life sciences : CMLS 2019 Dec;76(24):4905-4921
Cellular and molecular life sciences : CMLS 2019 Dec;76(24):4905-4921
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
Jiang E, Xu Z, Wang M, Yan T, Huang C, Zhou X, Liu Q, Wang L, Chen Y, Wang H, Liu K, Shao Z, Shang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5690-5703
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5690-5703
Prognostic value of monocarboxylate transporter 4 in patients with esophageal squamous cell carcinoma.
Cheng B, Chen X, Li Y, Huang X, Yu J
Oncology reports 2018 Nov;40(5):2906-2915
Oncology reports 2018 Nov;40(5):2906-2915
Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device.
Shi H, Jiang H, Wang L, Cao Y, Liu P, Xu X, Wang Y, Sun L, Niu H
Cell cycle (Georgetown, Tex.) 2015;14(19):3058-65
Cell cycle (Georgetown, Tex.) 2015;14(19):3058-65
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 22787-1-AP(SLC16A3 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SLC16A3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SLC16A3. This antibody recognizes human antigen. The SLC16A3 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 22787-1-AP(SLC16A3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 22787-1-AP(SLC16A3 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue