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- Antigen structure
- References [19]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10026-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10026-1-AP, RRID:AB_2161146
- Product name
- PDK1 antibody
- Antibody type
- Polyclonal
- Description
- PDK1 antibody (Cat. #10026-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca2+]m-PDP1-PDH-histone acetylation retrograde signaling.
Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice.
Deoxyelephantopin decreases the release of inflammatory cytokines in macrophage associated with attenuation of aerobic glycolysis via modulation of PKM2.
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China.
HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway.
The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer.
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.
Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer.
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway.
LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect.
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.
MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.
PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer.
ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.
Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.
A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1.
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Shi Y, Wang Y, Jiang H, Sun X, Xu H, Wei X, Wei Y, Xiao G, Song Z, Zhou F
Cell death & disease 2021 Sep 6;12(9):837
Cell death & disease 2021 Sep 6;12(9):837
Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice.
Zhang XM, Deng H, Tong JD, Wang YZ, Ning XC, Yang XH, Zhou FQ, Jin HM
Journal of diabetes research 2020;2020:2817972
Journal of diabetes research 2020;2020:2817972
Deoxyelephantopin decreases the release of inflammatory cytokines in macrophage associated with attenuation of aerobic glycolysis via modulation of PKM2.
Pan L, Hu L, Zhang L, Xu H, Chen Y, Bian Q, Zhu A, Wu H
International immunopharmacology 2020 Feb;79:106048
International immunopharmacology 2020 Feb;79:106048
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China.
Chen C, Luo F, Wu P, Huang Y, Das A, Chen S, Chen J, Hu X, Li F, Fang Z, Zhou S
Journal of cellular and molecular medicine 2020 Feb;24(4):2484-2496
Journal of cellular and molecular medicine 2020 Feb;24(4):2484-2496
HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway.
Xu WN, Zheng HL, Yang RZ, Jiang LS, Jiang SD
Frontiers in endocrinology 2019;10:922
Frontiers in endocrinology 2019;10:922
The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer.
Qin W, Tian Y, Zhang J, Liu W, Zhou Q, Hu S, Yang F, Lu L, Lu H, Cui S, Wen L, Wei S
Scientific reports 2019 Sep 10;9(1):12973
Scientific reports 2019 Sep 10;9(1):12973
Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation.
Zhou L, Wang Z, Hu C, Zhang C, Kovatcheva-Datchary P, Yu D, Liu S, Ren F, Wang X, Li Y, Hou X, Piao H, Lu X, Zhang Y, Xu G
Journal of proteome research 2019 Mar 1;18(3):960-969
Journal of proteome research 2019 Mar 1;18(3):960-969
Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer.
Peng W, Huang W, Ge X, Xue L, Zhao W, Xue J
EBioMedicine 2019 Jun;44:375-386
EBioMedicine 2019 Jun;44:375-386
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
Jiang E, Xu Z, Wang M, Yan T, Huang C, Zhou X, Liu Q, Wang L, Chen Y, Wang H, Liu K, Shao Z, Shang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5690-5703
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5690-5703
INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway.
Chen Y, Sun Z, Qi M, Wang X, Zhang W, Chen C, Liu J, Zhao W
Journal of cellular and molecular medicine 2018 May;22(5):2935-2943
Journal of cellular and molecular medicine 2018 May;22(5):2935-2943
LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect.
Xiang S, Gu H, Jin L, Thorne RF, Zhang XD, Wu M
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 13;115(7):E1465-E1474
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 13;115(7):E1465-E1474
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, Liang C, Meng Q, Xiang J, Liang D, Ji S, Liu J, Hu P, Liu L, Liu C, Long J, Ni Q, Yu X, Xu J
International journal of oncology 2017 May;50(5):1792-1800
International journal of oncology 2017 May;50(5):1792-1800
CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.
Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P
EMBO reports 2017 May;18(5):809-825
EMBO reports 2017 May;18(5):809-825
MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.
Zhu W, Huang Y, Pan Q, Xiang P, Xie N, Yu H
Digestive diseases and sciences 2017 Mar;62(3):660-668
Digestive diseases and sciences 2017 Mar;62(3):660-668
PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer.
Liu T, Yin H
Oncology reports 2017 Jan;37(1):193-200
Oncology reports 2017 Jan;37(1):193-200
ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.
Dong K, Ni H, Wu M, Tang Z, Halim M, Shi D
Biochemical and biophysical research communications 2016 Aug 5;476(4):204-211
Biochemical and biophysical research communications 2016 Aug 5;476(4):204-211
Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.
Xie HX, Xu ZY, Tang JN, DU YA, Huang L, Yu PF, Cheng XD
Experimental and therapeutic medicine 2015 Sep;10(3):1212-1218
Experimental and therapeutic medicine 2015 Sep;10(3):1212-1218
A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1.
Ying Q, Ansong E, Diamond AM, Yang W
International journal of molecular sciences 2015 Nov 18;16(11):27599-608
International journal of molecular sciences 2015 Nov 18;16(11):27599-608
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Yang R, Zhang M, Gustafson AR, Wang E, Cole MP, Tooley CE, Cheng A
Bioscience reports 2015 May 1;35(3)
Bioscience reports 2015 May 1;35(3)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 10026-1-AP(PDK1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 10026-1-AP(PDK1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDK1. This antibody recognizes human, mouse antigen. The PDK1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
