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LearnMAB350-100
antibody from R&D Systems
Targeting: CXCL12
PBSF, SCYB12, SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, TLSF-a, TLSF-b, TPAR1
ELISA
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [59]
- Comments [0]
- Validations
- Immunocytochemistry [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- MAB350-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Mouse CXCL12/SDF-1 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human and mouse CXCL12/SDF-1 alpha and CXCL12/SDF-1 beta in ELISAs.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
Q6ICW0- Isotype
- IgG
- Antibody clone number
- 79018
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells.
The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer.
Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigo.
CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression.
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma.
CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors.
Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema.
Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer.
Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin.
Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade.
The chronically inflamed central nervous system provides niches for long-lived plasma cells.
Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay.
SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy.
Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α1-67 in Patients With Type 2 Diabetes.
Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.
Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer.
CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney.
CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease.
CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.
Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies.
Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.
Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease.
Immunohistochemical evaluation of CXCL12-CXCR4 axis and VEGFR3 expression in primary urothelial cancer and its recurrence.
A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients.
Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice.
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.
The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells.
A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.
VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits.
Comprehensive assessment of chemokine expression profiles by flow cytometry.
CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.
Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss.
Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.
Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.
Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma.
Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.
Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells.
Skin homing of Sézary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV.
Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
Age-associated aortic stenosis in apolipoprotein E-deficient mice.
Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.
Characterization of hematopoietic progenitor mobilization in protease-deficient mice.
Thymic T cell development and progenitor localization depend on CCR7.
Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus.
Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
Lee GY, Jeong SY, Lee HR, Oh IH
Scientific reports 2019 Jan 30;9(1):1007
Scientific reports 2019 Jan 30;9(1):1007
The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer.
Wang M, Yang X, Wei M, Wang Z
Journal of Cancer 2018;9(21):3898-3903
Journal of Cancer 2018;9(21):3898-3903
Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigo.
Yoon JE, Kim Y, Kwon S, Kim M, Kim YH, Kim JH, Park TJ, Kang HY
Theranostics 2018;8(17):4620-4632
Theranostics 2018;8(17):4620-4632
CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression.
Raschioni C, Bottai G, Sagona A, Errico V, Testori A, Gatzemeier W, Corsi F, Tinterri C, Roncalli M, Santarpia L, Di Tommaso L
Disease markers 2018;2018:5018671
Disease markers 2018;2018:5018671
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma.
Kitawaki Y, Nakamura Y, Kubota-Nakayama F, Yamazaki Y, Miki Y, Hata S, Ise K, Kikuchi K, Morimoto R, Satoh F, Sasano H
Human pathology 2018 Jul;77:88-97
Human pathology 2018 Jul;77:88-97
CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors.
Marques CS, Santos AR, Gameiro A, Correia J, Ferreira F
BMC cancer 2018 Jul 16;18(1):741
BMC cancer 2018 Jul 16;18(1):741
Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema.
Tang W, Chen Y, Wang X, Chen Y, Zhang J, Lin Z
Oncology letters 2018 Feb;15(2):2501-2507
Oncology letters 2018 Feb;15(2):2501-2507
Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer.
Zhang J, Liu C, Mo X, Shi H, Li S
Oncology letters 2018 Feb;15(2):1771-1776
Oncology letters 2018 Feb;15(2):1771-1776
Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin.
Omland SH, Wettergren EE, Mollerup S, Asplund M, Mourier T, Hansen AJ, Gniadecki R
BMC cancer 2017 Oct 7;17(1):675
BMC cancer 2017 Oct 7;17(1):675
Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade.
Zboralski D, Hoehlig K, Eulberg D, Frömming A, Vater A
Cancer immunology research 2017 Nov;5(11):950-956
Cancer immunology research 2017 Nov;5(11):950-956
The chronically inflamed central nervous system provides niches for long-lived plasma cells.
Pollok K, Mothes R, Ulbricht C, Liebheit A, Gerken JD, Uhlmann S, Paul F, Niesner R, Radbruch H, Hauser AE
Acta neuropathologica communications 2017 Nov 25;5(1):88
Acta neuropathologica communications 2017 Nov 25;5(1):88
Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay.
Pierce H, Zhang D, Magnon C, Lucas D, Christin JR, Huggins M, Schwartz GJ, Frenette PS
Cell stem cell 2017 May 4;20(5):648-658.e4
Cell stem cell 2017 May 4;20(5):648-658.e4
SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy.
De-Colle C, Mönnich D, Welz S, Boeke S, Sipos B, Fend F, Mauz PS, Tinhofer I, Budach V, Jawad JA, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Bayer C, Belka C, Pigorsch S, Combs SE, Lohaus F, Linge A, Krause M, Baumann M, Zips D, Menegakis A
Clinical and translational radiation oncology 2017 Aug;5:28-36
Clinical and translational radiation oncology 2017 Aug;5:28-36
Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α1-67 in Patients With Type 2 Diabetes.
Lovshin JA, Rajasekeran H, Lytvyn Y, Lovblom LE, Khan S, Alemu R, Locke A, Lai V, He H, Hittle L, Wang W, Drucker DJ, Cherney DZI
Diabetes care 2017 Aug;40(8):1073-1081
Diabetes care 2017 Aug;40(8):1073-1081
Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.
McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL
The American journal of pathology 2017 Aug;187(8):1772-1786
The American journal of pathology 2017 Aug;187(8):1772-1786
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.
Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H
The EMBO journal 2017 Apr 3;36(7):840-853
The EMBO journal 2017 Apr 3;36(7):840-853
Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer.
Zhu X, Bai Q, Lu Y, Lu Y, Zhu L, Zhou X, Wu L
International journal of oncology 2016 Jun;48(6):2321-9
International journal of oncology 2016 Jun;48(6):2321-9
CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney.
Siddiqi FS, Chen LH, Advani SL, Thai K, Batchu SN, Alghamdi TA, White KE, Sood MM, Gibson IW, Connelly KA, Marsden PA, Advani A
Endocrinology 2015 Mar;156(3):1121-32
Endocrinology 2015 Mar;156(3):1121-32
CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
Geherin SA, Wilson RP, Jennrich S, Debes GF
PloS one 2014;9(4):e95626
PloS one 2014;9(4):e95626
SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease.
Chen LH, Advani SL, Thai K, Kabir MG, Sood MM, Gibson IW, Yuen DA, Connelly KA, Marsden PA, Kelly DJ, Gilbert RE, Advani A
PloS one 2014;9(3):e92227
PloS one 2014;9(3):e92227
CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.
Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB, Dwinell MB
PloS one 2014;9(3):e90400
PloS one 2014;9(3):e90400
Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies.
Sangaletti S, Tripodo C, Portararo P, Dugo M, Vitali C, Botti L, Guarnotta C, Cappetti B, Gulino A, Torselli I, Casalini P, Chiodoni C, Colombo MP
Oncoimmunology 2014;3:e28989
Oncoimmunology 2014;3:e28989
Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.
Walters MJ, Ebsworth K, Berahovich RD, Penfold ME, Liu SC, Al Omran R, Kioi M, Chernikova SB, Tseng D, Mulkearns-Hubert EE, Sinyuk M, Ransohoff RM, Lathia JD, Karamchandani J, Kohrt HE, Zhang P, Powers JP, Jaen JC, Schall TJ, Merchant M, Recht L, Brown JM
British journal of cancer 2014 Mar 4;110(5):1179-88
British journal of cancer 2014 Mar 4;110(5):1179-88
Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease.
Zhang WG, He L, Shi XM, Wu SS, Zhang B, Mei L, Xu YJ, Zhang ZX, Zhao JP, Zhang HL
Respiratory research 2014 Mar 25;15:33
Respiratory research 2014 Mar 25;15:33
Immunohistochemical evaluation of CXCL12-CXCR4 axis and VEGFR3 expression in primary urothelial cancer and its recurrence.
Batsi O, Giannopoulou I, Nesseris I, Valavanis C, Gakiopoulou H, Patsouris ES, Arapandoni-Dadioti P, Lazaris AC
Anticancer research 2014 Jul;34(7):3537-42
Anticancer research 2014 Jul;34(7):3537-42
A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients.
D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
International journal of cancer 2014 Jul 15;135(2):379-90
International journal of cancer 2014 Jul 15;135(2):379-90
Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
Pinto S, Martínez-Romero A, O'Connor JE, Gil-Benso R, San-Miguel T, Terrádez L, Monteagudo C, Callaghan RC
BMC cancer 2014 Feb 22;14:118
BMC cancer 2014 Feb 22;14:118
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
Klink B, Miletic H, Stieber D, Huszthy PC, Campos Valenzuela JA, Balss J, Wang J, Schubert M, Sakariassen PØ, Sundstrøm T, Torsvik A, Aarhus M, Mahesparan R, von Deimling A, Kaderali L, Niclou SP, Schröck E, Bjerkvig R, Nigro JM
PloS one 2013;8(3):e59773
PloS one 2013;8(3):e59773
CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice.
Akhtar S, Gremse F, Kiessling F, Weber C, Schober A
Arteriosclerosis, thrombosis, and vascular biology 2013 Apr;33(4):679-86
Arteriosclerosis, thrombosis, and vascular biology 2013 Apr;33(4):679-86
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.
Liberman J, Sartelet H, Flahaut M, Mühlethaler-Mottet A, Coulon A, Nyalendo C, Vassal G, Joseph JM, Gross N
PloS one 2012;7(8):e43665
PloS one 2012;7(8):e43665
The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells.
Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC
PloS one 2012;7(6):e38721
PloS one 2012;7(6):e38721
A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.
Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Australian Ovarian Cancer Study Group., Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR
Cancer research 2012 Jan 1;72(1):66-75
Cancer research 2012 Jan 1;72(1):66-75
VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits.
Roy H, Bhardwaj S, Babu M, Lähteenvuo JE, Ylä-Herttuala S
European journal of clinical investigation 2010 May;40(5):422-32
European journal of clinical investigation 2010 May;40(5):422-32
Comprehensive assessment of chemokine expression profiles by flow cytometry.
Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D
The Journal of clinical investigation 2010 Mar;120(3):907-23
The Journal of clinical investigation 2010 Mar;120(3):907-23
CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Sep;23(9):2928-41
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Sep;23(9):2928-41
Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.
Sayyed SG, Hägele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ
Diabetologia 2009 Nov;52(11):2445-54
Diabetologia 2009 Nov;52(11):2445-54
Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss.
Diamond P, Labrinidis A, Martin SK, Farrugia AN, Gronthos S, To LB, Fujii N, O'Loughlin PD, Evdokiou A, Zannettino AC
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 Jul;24(7):1150-61
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 Jul;24(7):1150-61
Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.
Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA, Shipley J
The Journal of pathology 2009 Jan;217(1):94-102
The Journal of pathology 2009 Jan;217(1):94-102
Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pità O, Girolomoni G, Sozzani S
The Journal of experimental medicine 2009 Jan 16;206(1):249-58
The Journal of experimental medicine 2009 Jan 16;206(1):249-58
Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.
Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, Huskens D, Luangsay S, Parmentier M, Geboes K, Schols D, Van Damme J, Proost P
Journal of immunology (Baltimore, Md. : 1950) 2009 Jan 1;182(1):666-74
Journal of immunology (Baltimore, Md. : 1950) 2009 Jan 1;182(1):666-74
Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
AIDS research and human retroviruses 2008 Mar;24(3):453-62
AIDS research and human retroviruses 2008 Mar;24(3):453-62
Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.
Tait LR, Pauley RJ, Santner SJ, Heppner GH, Heng HH, Rak JW, Miller FR
International journal of cancer 2007 May 15;120(10):2127-34
International journal of cancer 2007 May 15;120(10):2127-34
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
Blood 2007 May 15;109(10):4272-9
Blood 2007 May 15;109(10):4272-9
HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
AIDS (London, England) 2007 Jun 19;21(10):1263-72
AIDS (London, England) 2007 Jun 19;21(10):1263-72
Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 15;178(12):8148-57
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 15;178(12):8148-57
Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma.
Kleinman ME, Greives MR, Churgin SS, Blechman KM, Chang EI, Ceradini DJ, Tepper OM, Gurtner GC
Arteriosclerosis, thrombosis, and vascular biology 2007 Dec;27(12):2664-70
Arteriosclerosis, thrombosis, and vascular biology 2007 Dec;27(12):2664-70
Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.
Lisignoli G, Cristino S, Piacentini A, Cavallo C, Caplan AI, Facchini A
Journal of cellular physiology 2006 May;207(2):364-73
Journal of cellular physiology 2006 May;207(2):364-73
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Marchal-Sommé J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.
Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, Minami T, Nakayama T, Sakurai H, Takahashi Y, Yoshie O, Saiki I
Cancer research 2006 Feb 15;66(4):2181-7
Cancer research 2006 Feb 15;66(4):2181-7
Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells.
Infantino S, Moepps B, Thelen M
Journal of immunology (Baltimore, Md. : 1950) 2006 Feb 15;176(4):2197-207
Journal of immunology (Baltimore, Md. : 1950) 2006 Feb 15;176(4):2197-207
Skin homing of Sézary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV.
Narducci MG, Scala E, Bresin A, Caprini E, Picchio MC, Remotti D, Ragone G, Nasorri F, Frontani M, Arcelli D, Volinia S, Lombardo GA, Baliva G, Napolitano M, Russo G
Blood 2006 Feb 1;107(3):1108-15
Blood 2006 Feb 1;107(3):1108-15
Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H
Cardiovascular research 2006 Aug 1;71(3):455-65
Cardiovascular research 2006 Aug 1;71(3):455-65
Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS
Bone 2006 Apr;38(4):497-508
Bone 2006 Apr;38(4):497-508
Age-associated aortic stenosis in apolipoprotein E-deficient mice.
Tanaka K, Sata M, Fukuda D, Suematsu Y, Motomura N, Takamoto S, Hirata Y, Nagai R
Journal of the American College of Cardiology 2005 Jul 5;46(1):134-41
Journal of the American College of Cardiology 2005 Jul 5;46(1):134-41
Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.
Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005 Jan;23(1):203-9
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2005 Jan;23(1):203-9
Characterization of hematopoietic progenitor mobilization in protease-deficient mice.
Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC
Blood 2004 Jul 1;104(1):65-72
Blood 2004 Jul 1;104(1):65-72
Thymic T cell development and progenitor localization depend on CCR7.
Misslitz A, Pabst O, Hintzen G, Ohl L, Kremmer E, Petrie HT, Förster R
The Journal of experimental medicine 2004 Aug 16;200(4):481-91
The Journal of experimental medicine 2004 Aug 16;200(4):481-91
Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus.
Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E, Peled A
European journal of immunology 2004 Apr;34(4):1164-74
European journal of immunology 2004 Apr;34(4):1164-74
Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, Wyvill K, Little R, Yarchoan R, Tosato G
Journal of leukocyte biology 2003 Nov;74(5):880-8
Journal of leukocyte biology 2003 Nov;74(5):880-8
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- CXCL12/SDF-1 in Human PBMCs and K562 Human Cell Line. CXCL12/SDF-1 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs; positive staining) and K562 human chronic myelogenous leukemia cell line (negative staining) using Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350) at 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cell membranes. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- CXCL12/SDF-1 in Human Tonsil. CXCL12/SDF-1 was detected in immersion fixed paraffin-embedded sections of human tonsil using 15 µg/mL Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to epithelial cells in cripts. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- CXCL12/SDF-1 in Human Tonsil. CXCL12/SDF-1 was detected in immersion fixed paraffin-embedded sections of human tonsil using Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CXCL12/SDF-1 in HT1080 Human Cell Line by Flow Cytometry. HT1080 human fibrosarcoma cell line was stained with Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). To facilitate intracellular staining, cells were fixed and permeabilized with FlowX FoxP3 Fixation & Permeabilization Buffer Kit (Catalog # FC012). View our protocol for Staining Intracellular Molecules.
