Antibody data

Product number
BS60749 - Provider product page
Provider
Bioworld Technology, Inc
Product name
TOP3A polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human TOP3A
Description
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I (Topo I) and Topo II relax both positive and negative supercoils, Topo III relaxes only negative supercoils. Topo IIIÏ« exists as a long and a short isoform, which are produced by alternative splicing. Topo IIIÏ«, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. Topo IIIÉÇ exists as three isoforms,ÉÇ-1,ÉÇ -2 and ÉÇ-3, also produced by alternative splicing. Topo IIIÉÇ-1 is expressed in testis, heart, and skeletal muscle, whereas Topo IIIÉÇ-2 is expressed in thymus, kidney and pancreas.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TOP3A protein structure - BS60749 shown in red.