abx001152

ERG antibody from Abbexa
erg-3, p55
Western blot
Recommended by provider
Immunocytochemistry
Recommended by provider

Antibody data

Product number
abx001152
Provider
Abbexa
Product name
Transcriptional Regulator ERG (ERG) Antibody
Provider product page
Abbexa - abx001152
Antibody type
Polyclonal
Description
ERG Antibody is a Rabbit Polyclonal antibody against ERG. This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2012].
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µl
Concentration
> 1 mg/ml
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Provider Type Product Number
- No reagents -