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- References [69]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10449-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10449-1-AP, RRID:AB_2168724
- Product name
- GADD34 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GADD34 antibody (Cat. #10449-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury.
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Activation of the Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Pathway of the Unfolded Protein Response after Experimental Traumatic Brain Injury and Treatment with a PERK Inhibitor.
The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases.
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids.
Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis.
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
GADD34 is a modulator of autophagy during starvation.
The endoplasmic reticulum stress induced by tunicamycin affects the viability and autophagy activity of chondrocytes.
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
CReP mediates selective translation initiation at the endoplasmic reticulum.
Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
GADD34 attenuates HIV-1 replication by viral 5'-UTR TAR RNA-mediated translational inhibition.
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation.
Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress.
Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.
Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation.
Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death.
Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease.
Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats.
ICE1 promotes the link between splicing and nonsense-mediated mRNA decay.
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes.
Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Activating Transcription Factor-6α Deletion Modulates the Endoplasmic Reticulum Stress Response after Spinal Cord Injury but Does Not Affect Locomotor Recovery.
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.
Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells.
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.
Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.
Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.
Oral proteasome inhibitor with strong preclinical efficacy in myeloma models.
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.
Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation.
The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.
The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma.
Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.
Failure of amino acid homeostasis causes cell death following proteasome inhibition.
Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis.
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.
Li L, Luo Q, Shang B, Yang X, Zhang Y, Pan Q, Wu N, Tang W, Du D, Sun X, Jiang L
Experimental neurology 2022 Jan;347:113899
Experimental neurology 2022 Jan;347:113899
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Alfred N, Qian B, Qin X, Yin X, Prajapati M, Dou Y, Li Y, Zhang Z
Frontiers in veterinary science 2021;8:645571
Frontiers in veterinary science 2021;8:645571
Activation of the Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Pathway of the Unfolded Protein Response after Experimental Traumatic Brain Injury and Treatment with a PERK Inhibitor.
Brady RD, Bird S, Sun M, Yamakawa GR, Major BP, Mychasiuk R, O'Brien TJ, McDonald SJ, Shultz SR
Neurotrauma reports 2021;2(1):330-342
Neurotrauma reports 2021;2(1):330-342
The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases.
Gan G, Shi Z, Shangguan C, Zhang J, Yuan Y, Chen L, Liu W, Li B, Meng S, Xiong W, Mi J
Theranostics 2021;11(12):6006-6018
Theranostics 2021;11(12):6006-6018
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Chang L, Liu X, Chen J, Liu H, Wang G, Wang G, Liao X, Shen X
Journal of molecular neuroscience : MN 2021 Oct 13;
Journal of molecular neuroscience : MN 2021 Oct 13;
The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids.
Miles RR, Amin PH, Diaz MB, Misra J, Aukerman E, Das A, Ghosh N, Guith T, Knierman MD, Roy S, Spandau DF, Wek RC
The Journal of biological chemistry 2021 Nov;297(5):101257
The Journal of biological chemistry 2021 Nov;297(5):101257
Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Monkley S, Overed-Sayer C, Parfrey H, Rassl D, Crowther D, Escudero-Ibarz L, Davis N, Carruthers A, Berks R, Coetzee M, Kolosionek E, Karlsson M, Griffin LR, Clausen M, Belfield G, Hogaboam CM, Murray LA
Scientific reports 2021 Nov 3;11(1):21584
Scientific reports 2021 Nov 3;11(1):21584
Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis.
Al-Yacoub N, Colak D, Mahmoud SA, Hammonds M, Muhammed K, Al-Harazi O, Assiri AM, Al-Buraiki J, Al-Habeeb W, Poizat C
Communications biology 2021 Jul 16;4(1):884
Communications biology 2021 Jul 16;4(1):884
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
Arioka Y, Shishido E, Kushima I, Suzuki T, Saito R, Aiba A, Mori D, Ozaki N
EBioMedicine 2021 Jan;63:103138
EBioMedicine 2021 Jan;63:103138
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
Xu H, Bensalel J, Capobianco E, Lu ML, Wei J
Cellular and molecular neurobiology 2021 Aug 4;
Cellular and molecular neurobiology 2021 Aug 4;
GADD34 is a modulator of autophagy during starvation.
Gambardella G, Staiano L, Moretti MN, De Cegli R, Fagnocchi L, Di Tullio G, Polletti S, Braccia C, Armirotti A, Zippo A, Ballabio A, De Matteis MA, di Bernardo D
Science advances 2020 Sep;6(39)
Science advances 2020 Sep;6(39)
The endoplasmic reticulum stress induced by tunicamycin affects the viability and autophagy activity of chondrocytes.
Wu H, Meng Z, Jiao Y, Ren Y, Yang X, Liu H, Wang R, Cui Y, Pan L, Cao Y
Journal of clinical laboratory analysis 2020 Oct;34(10):e23437
Journal of clinical laboratory analysis 2020 Oct;34(10):e23437
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
Wang F, Liu L, Tong Y, Li L, Liu Y, Gao WQ
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):541-550
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):541-550
Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR
Neuron 2020 Mar 4;105(5):855-866.e5
Neuron 2020 Mar 4;105(5):855-866.e5
CReP mediates selective translation initiation at the endoplasmic reticulum.
Kastan JP, Dobrikova EY, Bryant JD, Gromeier M
Science advances 2020 Jun;6(23):eaba0745
Science advances 2020 Jun;6(23):eaba0745
Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.
Rao L, Xu Y, Reineke LC, Bhattacharya A, Tyryshkin A, Shin JN, Eissa NT
International journal of molecular sciences 2020 Jun 17;21(12)
International journal of molecular sciences 2020 Jun 17;21(12)
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.
Lu Y, Sun Y, Liu Z, Lu Y, Zhu X, Lan B, Mi Z, Dang L, Li N, Zhan W, Tan L, Pi J, Xiong H, Zhang L, Chen Y
Science translational medicine 2020 Jul 29;12(554)
Science translational medicine 2020 Jul 29;12(554)
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
Sicari D, Delaunay-Moisan A, Combettes L, Chevet E, Igbaria A
The FEBS journal 2020 Jan;287(1):27-42
The FEBS journal 2020 Jan;287(1):27-42
GADD34 attenuates HIV-1 replication by viral 5'-UTR TAR RNA-mediated translational inhibition.
Ishaq M, Marshall H, Natarajan V
Virology 2020 Jan 15;540:119-131
Virology 2020 Jan 15;540:119-131
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation.
Shrestha P, Ayata P, Herrero-Vidal P, Longo F, Gastone A, LeDoux JE, Heintz N, Klann E
Nature neuroscience 2020 Feb;23(2):281-292
Nature neuroscience 2020 Feb;23(2):281-292
Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Gokhale NS, McIntyre ABR, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM
Molecular cell 2020 Feb 6;77(3):542-555.e8
Molecular cell 2020 Feb 6;77(3):542-555.e8
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
Young-Baird SK, Lourenço MB, Elder MK, Klann E, Liebau S, Dever TE
Molecular cell 2020 Feb 20;77(4):875-886.e7
Molecular cell 2020 Feb 20;77(4):875-886.e7
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
Gao P, Chai Y, Song J, Liu T, Chen P, Zhou L, Ge X, Guo X, Han J, Yang H
PLoS pathogens 2019 Nov;15(11):e1008169
PLoS pathogens 2019 Nov;15(11):e1008169
Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress.
Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim MJ, Machnicka K, Liszewska E, Jaworski J, Chacinska A
Molecular biology of the cell 2019 Jul 15;30(15):1864-1877
Molecular biology of the cell 2019 Jul 15;30(15):1864-1877
Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.
Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ
Scientific reports 2019 Feb 27;9(1):2903
Scientific reports 2019 Feb 27;9(1):2903
Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation.
Peng X, Yang T, He L, Chen X, Jiang Y, Zhang H, Liu H, Peng Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2203-2215
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2203-2215
Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death.
Johnson CE, Dunlop EA, Seifan S, McCann HD, Hay T, Parfitt GJ, Jones AT, Giles PJ, Shen MH, Sampson JR, Errington RJ, Davies DM, Tee AR
Oncogene 2018 Nov;37(45):5913-5925
Oncogene 2018 Nov;37(45):5913-5925
Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease.
Sun X, Aimé P, Dai D, Ramalingam N, Crary JF, Burke RE, Greene LA, Levy OA
Experimental neurology 2018 May;303:95-107
Experimental neurology 2018 May;303:95-107
Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats.
Melas PA, Qvist JS, Deidda M, Upreti C, Wei YB, Sanna F, Fratta W, Scherma M, Fadda P, Kandel DB, Kandel ER
Cell reports 2018 Mar 13;22(11):2909-2923
Cell reports 2018 Mar 13;22(11):2909-2923
ICE1 promotes the link between splicing and nonsense-mediated mRNA decay.
Baird TD, Cheng KC, Chen YC, Buehler E, Martin SE, Inglese J, Hogg JR
eLife 2018 Mar 12;7
eLife 2018 Mar 12;7
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
Moon SL, Parker R
RNA (New York, N.Y.) 2018 Jun;24(6):841-852
RNA (New York, N.Y.) 2018 Jun;24(6):841-852
Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes.
Collier AE, Spandau DF, Wek RC
Molecular biology of the cell 2018 Jan 1;29(1):29-41
Molecular biology of the cell 2018 Jan 1;29(1):29-41
Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
Lee IC, Ho XY, George SE, Goh CW, Sundaram JR, Pang KKL, Luo W, Yusoff P, Sze NSK, Shenolikar S
Cell death and differentiation 2018 Feb;25(2):255-267
Cell death and differentiation 2018 Feb;25(2):255-267
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Hyer ML, Milhollen MA, Ciavarri J, Fleming P, Traore T, Sappal D, Huck J, Shi J, Gavin J, Brownell J, Yang Y, Stringer B, Griffin R, Bruzzese F, Soucy T, Duffy J, Rabino C, Riceberg J, Hoar K, Lublinsky A, Menon S, Sintchak M, Bump N, Pulukuri SM, Langston S, Tirrell S, Kuranda M, Veiby P, Newcomb J, Li P, Wu JT, Powe J, Dick LR, Greenspan P, Galvin K, Manfredi M, Claiborne C, Amidon BS, Bence NF
Nature medicine 2018 Feb;24(2):186-193
Nature medicine 2018 Feb;24(2):186-193
Activating Transcription Factor-6α Deletion Modulates the Endoplasmic Reticulum Stress Response after Spinal Cord Injury but Does Not Affect Locomotor Recovery.
Saraswat Ohri S, Mullins A, Hetman M, Whittemore SR
Journal of neurotrauma 2018 Feb 1;35(3):486-491
Journal of neurotrauma 2018 Feb 1;35(3):486-491
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.
Krzyzosiak A, Sigurdardottir A, Luh L, Carrara M, Das I, Schneider K, Bertolotti A
Cell 2018 Aug 23;174(5):1216-1228.e19
Cell 2018 Aug 23;174(5):1216-1228.e19
Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.
Dolinay T, Aonbangkhen C, Zacharias W, Cantu E, Pogoriler J, Stablow A, Lawrence GG, Suzuki Y, Chenoweth DM, Morrisey E, Christie JD, Beers MF, Margulies SS
Respiratory research 2018 Aug 22;19(1):157
Respiratory research 2018 Aug 22;19(1):157
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
Chang TK, Lawrence DA, Lu M, Tan J, Harnoss JM, Marsters SA, Liu P, Sandoval W, Martin SE, Ashkenazi A
Molecular cell 2018 Aug 16;71(4):629-636.e5
Molecular cell 2018 Aug 16;71(4):629-636.e5
Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.
Shelkovnikova TA, Dimasi P, Kukharsky MS, An H, Quintiero A, Schirmer C, Buée L, Galas MC, Buchman VL
Cell death & disease 2017 May 11;8(5):e2788
Cell death & disease 2017 May 11;8(5):e2788
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
Dalet A, Argüello RJ, Combes A, Spinelli L, Jaeger S, Fallet M, Vu Manh TP, Mendes A, Perego J, Reverendo M, Camosseto V, Dalod M, Weil T, Santos MA, Gatti E, Pierre P
The EMBO journal 2017 Mar 15;36(6):761-782
The EMBO journal 2017 Mar 15;36(6):761-782
Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells.
Dunlop EA, Johnson CE, Wiltshire M, Errington RJ, Tee AR
Oncotarget 2017 Jul 25;8(30):48711-48724
Oncotarget 2017 Jul 25;8(30):48711-48724
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.
Crespillo-Casado A, Chambers JE, Fischer PM, Marciniak SJ, Ron D
eLife 2017 Apr 27;6
eLife 2017 Apr 27;6
Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.
Sidoli M, Musner N, Silvestri N, Ungaro D, D'Antonio M, Cavener DR, Feltri ML, Wrabetz L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Nov 2;36(44):11350-11361
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Nov 2;36(44):11350-11361
Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.
Musner N, Sidoli M, Zambroni D, Del Carro U, Ungaro D, D'Antonio M, Feltri ML, Wrabetz L
ASN neuro 2016 Mar-Apr;8(2)
ASN neuro 2016 Mar-Apr;8(2)
Oral proteasome inhibitor with strong preclinical efficacy in myeloma models.
Park J, Park E, Jung CK, Kang SW, Kim BG, Jung Y, Kim TH, Lim JY, Lee SE, Min CK, Won KA
BMC cancer 2016 Mar 24;16:247
BMC cancer 2016 Mar 24;16:247
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
Young SK, Shao Y, Bidwell JP, Wek RC
The Journal of biological chemistry 2016 Jun 24;291(26):13780-8
The Journal of biological chemistry 2016 Jun 24;291(26):13780-8
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
De Gassart A, Bujisic B, Zaffalon L, Decosterd LA, Di Micco A, Frera G, Tallant R, Martinon F
Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 12;113(2):E117-26
Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 12;113(2):E117-26
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.
Radford H, Moreno JA, Verity N, Halliday M, Mallucci GR
Acta neuropathologica 2015 Nov;130(5):633-42
Acta neuropathologica 2015 Nov;130(5):633-42
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.
Young SK, Willy JA, Wu C, Sachs MS, Wek RC
The Journal of biological chemistry 2015 Nov 20;290(47):28257-28271
The Journal of biological chemistry 2015 Nov 20;290(47):28257-28271
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
Chambers JE, Dalton LE, Clarke HJ, Malzer E, Dominicus CS, Patel V, Moorhead G, Ron D, Marciniak SJ
eLife 2015 Mar 16;4
eLife 2015 Mar 16;4
DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP
PLoS genetics 2015 Jun;11(6):e1005292
PLoS genetics 2015 Jun;11(6):e1005292
Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.
van 't Wout EF, van Schadewijk A, van Boxtel R, Dalton LE, Clarke HJ, Tommassen J, Marciniak SJ, Hiemstra PS
PLoS pathogens 2015 Jun;11(6):e1004946
PLoS pathogens 2015 Jun;11(6):e1004946
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, Hong L, Fan X, Chen Q, Tian J, Jiang M, Sun X, Jin C, Yin ZY, Liu Q, Zhang J, Qin F, Lin KH, Yu JS, Deng X, Wang HR, Zhao B, Johnson RL, Chen L, Zhou D
Nature communications 2015 Feb 19;6:6239
Nature communications 2015 Feb 19;6:6239
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.
Das I, Krzyzosiak A, Schneider K, Wrabetz L, D'Antonio M, Barry N, Sigurdardottir A, Bertolotti A
Science (New York, N.Y.) 2015 Apr 10;348(6231):239-42
Science (New York, N.Y.) 2015 Apr 10;348(6231):239-42
Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R
PloS one 2014;9(7):e101643
PloS one 2014;9(7):e101643
The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.
Parfitt DA, Aguila M, McCulley CH, Bevilacqua D, Mendes HF, Athanasiou D, Novoselov SS, Kanuga N, Munro PM, Coffey PJ, Kalmar B, Greensmith L, Cheetham ME
Cell death & disease 2014 May 22;5:e1236
Cell death & disease 2014 May 22;5:e1236
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
Besche HC, Sha Z, Kukushkin NV, Peth A, Hock EM, Kim W, Gygi S, Gutierrez JA, Liao H, Dick L, Goldberg AL
The EMBO journal 2014 May 16;33(10):1159-76
The EMBO journal 2014 May 16;33(10):1159-76
The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation.
Ozasa R, Okada T, Nadanaka S, Nagamine T, Zyryanova A, Harding H, Ron D, Mori K
Cell structure and function 2013;38(2):183-95
Cell structure and function 2013;38(2):183-95
The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.
Nagelkerke A, Bussink J, van der Kogel AJ, Sweep FC, Span PN
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):415-21
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):415-21
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
Thomas SE, Malzer E, Ordóñez A, Dalton LE, van T Wout EFA, Liniker E, Crowther DC, Lomas DA, Marciniak SJ
The Journal of biological chemistry 2013 Mar 15;288(11):7606-7617
The Journal of biological chemistry 2013 Mar 15;288(11):7606-7617
Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.
Hahn CK, Lowrey CH
Blood 2013 Jul 25;122(4):477-85
Blood 2013 Jul 25;122(4):477-85
The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma.
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 10449-1-AP(GADD34 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10449-1-AP(GADD34 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GADD34 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GADD34. This antibody recognizes human antigen. The GADD34 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
