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- Antibody Data
- Antigen structure
- References [30]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- 13241-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- CYP1A1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CYP1A1 antibody (Cat. #13241-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, pig and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Regioselective hydroxylation of carbendazim by mammalian cytochrome P450: A combined experimental and computational study.
Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR-miR-429 pathway.
Assessment of fibrotic pathways induced by environmental chemicals using 3D-human liver microtissue model.
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma.
Chrysophanol protects human bronchial epithelial cells from cigarette smoke extract (CSE)-induced apoptosis.
MiR-124a Mediates the Impairment of Intestinal Epithelial Integrity by Targeting Aryl Hydrocarbon Receptor in Crohn's Disease.
Cigarette smoke extract stimulates bronchial epithelial cells to undergo a SUMOylation turnover.
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-κB activation.
Oct4 plays a role in 2, 3, 7, 8 - tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation.
Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink.
Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line.
In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease.
Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes.
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Bisphenol A affects estradiol metabolism by targeting CYP1A1 and CYP19A1 in human placental JEG-3 cells.
CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.
Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity.
Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.
6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression.
Aryl hydrocarbon receptor activation maintained the intestinal epithelial barrier function through Notch1 dependent signaling pathway.
Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.
Hydroxylation and sulfation of sex steroid hormones in inflammatory liver.
Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes.
The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.
Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells.
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Lv X, Li JX, Wang JY, Tian XG, Feng L, Sun CP, Ning J, Wang C, Zhao WY, Li YC, Ma XC
Environmental pollution (Barking, Essex : 1987) 2022 Jan 15;293:118523
Environmental pollution (Barking, Essex : 1987) 2022 Jan 15;293:118523
Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR-miR-429 pathway.
Chu Y, Zhu Y, Zhang Y, Liu X, Guo Y, Chang L, Yun X, Wei Z, Xia Y, Dai Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21502
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21502
Assessment of fibrotic pathways induced by environmental chemicals using 3D-human liver microtissue model.
Yan L, Messner CJ, Zhang X, Suter-Dick L
Environmental research 2021 Mar;194:110679
Environmental research 2021 Mar;194:110679
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
Li H, Wang YG, Ma ZC, Yun-Hang G, Ling S, Teng-Fei C, Guang-Ping Z, Gao Y
Xenobiotica; the fate of foreign compounds in biological systems 2021 Jul;51(7):752-763
Xenobiotica; the fate of foreign compounds in biological systems 2021 Jul;51(7):752-763
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ
Free radical biology & medicine 2021 Feb 1;163:102-115
Free radical biology & medicine 2021 Feb 1;163:102-115
AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma.
Zhu Q, Ma Y, Liang J, Wei Z, Li M, Zhang Y, Liu M, He H, Qu C, Cai J, Wang X, Zeng Y, Jiao Y
Signal transduction and targeted therapy 2021 Aug 9;6(1):299
Signal transduction and targeted therapy 2021 Aug 9;6(1):299
Chrysophanol protects human bronchial epithelial cells from cigarette smoke extract (CSE)-induced apoptosis.
Wu G, Yuan T, Zhu H, Zhang H, Su J, Guo L, Zhou Q, Xiong F, Yu Q, Yang P, Zhang S, Mo B, Zhao J, Cai J, Wang CY
International journal of molecular epidemiology and genetics 2020;11(3):39-45
International journal of molecular epidemiology and genetics 2020;11(3):39-45
MiR-124a Mediates the Impairment of Intestinal Epithelial Integrity by Targeting Aryl Hydrocarbon Receptor in Crohn's Disease.
Zhao X, Li J, Ma J, Jiao C, Qiu X, Cui X, Wang D, Zhang H
Inflammation 2020 Oct;43(5):1862-1875
Inflammation 2020 Oct;43(5):1862-1875
Cigarette smoke extract stimulates bronchial epithelial cells to undergo a SUMOylation turnover.
Zhou H, Zhang L, Li Y, Wu G, Zhu H, Zhang H, Su JK, Guo L, Zhou Q, Xiong F, Yu Q, Yang P, Zhang S, Cai J, Wang CY
BMC pulmonary medicine 2020 Oct 23;20(1):276
BMC pulmonary medicine 2020 Oct 23;20(1):276
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-κB activation.
Tian LX, Tang X, Ma W, Wang J, Zhang W, Liu K, Chen T, Zhu JY, Liang HP
FEBS open bio 2020 Nov;10(11):2316-2328
FEBS open bio 2020 Nov;10(11):2316-2328
Oct4 plays a role in 2, 3, 7, 8 - tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation.
Tao Y, Liu X, Cui L, Liu X, Chen Y, He Z, Ji M, Gao Z, Li N, Wan Z, Yu Z
Toxicology 2020 May 30;438:152444
Toxicology 2020 May 30;438:152444
Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink.
Akintade DD, Chaudhuri B
Sensors (Basel, Switzerland) 2020 Jul 21;20(14)
Sensors (Basel, Switzerland) 2020 Jul 21;20(14)
Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line.
Ranjit S, Kodidela S, Sinha N, Chauhan S, Kumar S
Viruses 2020 Feb 21;12(2)
Viruses 2020 Feb 21;12(2)
In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease.
Zhu XY, Xia HG, Wang ZH, Li B, Jiang HY, Li DL, Jin R, Jin Y
Toxicology letters 2020 Feb 1;319:85-94
Toxicology letters 2020 Feb 1;319:85-94
Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes.
Wang X, Li S, Liu L, Jian Z, Cui T, Yang Y, Guo S, Yi X, Wang G, Li C, Gao T, Li K
Journal of dermatological science 2019 Oct;96(1):33-41
Journal of dermatological science 2019 Oct;96(1):33-41
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
Xia H, Zhu X, Zhang X, Jiang H, Li B, Wang Z, Li D, Jin Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109287
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109287
Bisphenol A affects estradiol metabolism by targeting CYP1A1 and CYP19A1 in human placental JEG-3 cells.
Xu H, Zhang X, Ye Y, Li X
Toxicology in vitro : an international journal published in association with BIBRA 2019 Dec;61:104615
Toxicology in vitro : an international journal published in association with BIBRA 2019 Dec;61:104615
CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.
Sonawane VR, Siddique MUM, Gatchie L, Williams IS, Bharate SB, Jayaprakash V, Sinha BN, Chaudhuri B
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Apr 1;131:177-194
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Apr 1;131:177-194
Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity.
Yu M, Wang Q, Ma Y, Li L, Yu K, Zhang Z, Chen G, Li X, Xiao W, Xu P, Yang H
International journal of biological sciences 2018;14(1):69-77
International journal of biological sciences 2018;14(1):69-77
Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.
Huang B, Bao J, Cao YR, Gao HF, Jin Y
Biochemistry. Biokhimiia 2018 May;83(5):595-602
Biochemistry. Biokhimiia 2018 May;83(5):595-602
6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression.
Ma Y, Wang Q, Yu K, Fan X, Xiao W, Cai Y, Xu P, Yu M, Yang H
Chemico-biological interactions 2018 May 25;288:83-90
Chemico-biological interactions 2018 May 25;288:83-90
Aryl hydrocarbon receptor activation maintained the intestinal epithelial barrier function through Notch1 dependent signaling pathway.
Liu Z, Li L, Chen W, Wang Q, Xiao W, Ma Y, Sheng B, Li X, Sun L, Yu M, Yang H
International journal of molecular medicine 2018 Mar;41(3):1560-1572
International journal of molecular medicine 2018 Mar;41(3):1560-1572
Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2/p‑MK2/TTP pathway.
Wang Q, Yang K, Han B, Sheng B, Yin J, Pu A, Li L, Sun L, Yu M, Qiu Y, Xiao W, Yang H
International journal of molecular medicine 2018 Feb;41(2):868-876
International journal of molecular medicine 2018 Feb;41(2):868-876
Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells.
Sharma R, Williams IS, Gatchie L, Sonawane VR, Chaudhuri B, Bharate SB
Bioorganic & medicinal chemistry 2018 Dec 15;26(23-24):6076-6086
Bioorganic & medicinal chemistry 2018 Dec 15;26(23-24):6076-6086
Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1.
Sharma R, Williams IS, Gatchie L, Sonawane VR, Chaudhuri B, Bharate SB
ACS omega 2018 Aug 31;3(8):8553-8566
ACS omega 2018 Aug 31;3(8):8553-8566
Hydroxylation and sulfation of sex steroid hormones in inflammatory liver.
Lee SR, Lee SY, Kim SY, Ryu SY, Park BK, Hong EJ
Journal of biomedical research 2017 Sep 26;31(5):437-444
Journal of biomedical research 2017 Sep 26;31(5):437-444
Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes.
Liu Q, Wu J, Song J, Liang P, Zheng K, Xiao G, Liu L, Zouboulis CC, Lei T
International journal of molecular medicine 2017 Oct;40(4):1029-1036
International journal of molecular medicine 2017 Oct;40(4):1029-1036
The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.
Yin J, Sheng B, Han B, Pu A, Yang K, Li P, Wang Q, Xiao W, Yang H
Cell biology international 2016 May;40(5):560-8
Cell biology international 2016 May;40(5):560-8
Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells.
Yin J, Sheng B, Pu A, Han B, Yang K, Wang Q, Sun L, Yang H
Digestive diseases and sciences 2016 Feb;61(2):444-52
Digestive diseases and sciences 2016 Feb;61(2):444-52
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Zhang B, Liu Y, Li X
Toxins 2015 Mar 30;7(4):1102-15
Toxins 2015 Mar 30;7(4):1102-15
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with 13241-1-AP(CYP1A1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 13241-1-AP(CYP1A1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYP1A1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CYP1A1. This antibody recognizes human, mouse antigen. The CYP1A1 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
