BS6923

antibody from Bioworld Technology, Inc
Targeting: KCNQ1 JLNS1, KCNA8, KCNA9, Kv7.1, KVLQT1, LQT, LQT1
Provider product page for BS6923
Western blot
Immunohistochemistry

Antibody data

Product number
BS6923 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Kv7.1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Kv7.1.
Description
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an Ï« subunit KCNQ1 and a ÉÇ subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
KCNQ1 protein structure - BS6923 shown in red.