Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
Reference
Comment
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- Product number
- 20995-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20995-1-AP, RRID:AB_10694293
- Product name
- TMEM106B antibody
- Antibody type
- Polyclonal
- Description
- TMEM106B antibody (Cat. #20995-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.
TMEM106B expression is reduced in Alzheimer's disease brains.
TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.
Jun MH, Han JH, Lee YK, Jang DJ, Kaang BK, Lee JA
Molecular brain 2015 Dec 10;8:85
Molecular brain 2015 Dec 10;8:85
TMEM106B expression is reduced in Alzheimer's disease brains.
Satoh J, Kino Y, Kawana N, Yamamoto Y, Ishida T, Saito Y, Arima K
Alzheimer's research & therapy 2014;6(2):17
Alzheimer's research & therapy 2014;6(2):17
TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.
Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Aug 15;32(33):11213-27
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Aug 15;32(33):11213-27
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 20995-1-AP(TMEM106B antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TMEM106B (IP:20995-1-AP, 3ug; Detection:20995-1-AP 1:1000) with mouse brain tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 20995-1-AP(TMEM106B antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TMEM106B antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TMEM106B. This antibody recognizes human, mouse antigen. The TMEM106B antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.