BS2144

antibody from Bioworld Technology, Inc
Targeting: BRMS1 DKFZP564A063
Provider product page for BS2144
Western blot
Immunohistochemistry

Antibody data

Product number
BS2144 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BRMS 1 (E43) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 210-58 of Human BRMS-1.
Description
Breast cancer metastasis-suppressor 1 (BRMS1) acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NF°ÙB activity.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BRMS1 protein structure - BS2144 shown in red.