11073-2-AP
antibody from Proteintech Group
Targeting: CXCR4
CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R
Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
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Validation data
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- Product number
- 11073-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11073-2-AP, RRID:AB_2091813
- Product name
- CXCR4 antibody
- Antibody type
- Polyclonal
- Description
- CXCR4 antibody (Cat. #11073-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Increased tumor-infiltrating plasmacytoid dendritic cells promote cancer cell proliferation and invasion via TNF-α/NF-κB/CXCR-4 pathway in oral squamous cell carcinoma.
Cancer-associated fibroblasts in gastric cancer affect malignant progression via the CXCL12-CXCR4 axis.
Bioengineering CXCR4-overexpressing cell membrane functionalized ROS-responsive nanotherapeutics for targeting cerebral ischemia-reperfusion injury.
Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.
CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c-Met signaling pathway.
Vincetoxicum arnottianum modulates motility features and metastatic marker expression in pediatric rhabdomyosarcoma by stabilizing the actin cytoskeleton.
Construction and a preliminary study of paracrine effect of bone marrow-derived endothelial progenitor cell sheet.
A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis.
Pretreatment with licochalcone a enhances therapeutic activity of rat bone marrow mesenchymal stem cells in animal models of colitis.
miR-204-5p Suppress Lymph Node Metastasis via Regulating CXCL12 and CXCR4 in Gastric Cancer.
MiR-645 promotes invasiveness, metastasis and tumor growth in colorectal cancer by targeting EFNA5.
LncRNA-cCSC1 modulates cancer stem cell properties in colorectal cancer via activation of the Hedgehog signaling pathway.
CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model.
N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.
Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1.
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1/CXCR4 and mSCF/Kit-ETV1 Pathways in the Stomach of Diabetic Mice.
Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811.
The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration.
Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system.
Han N, Li X, Wang Y, Wang L, Zhang C, Zhang Z, Ruan M, Zhang C
Journal of Cancer 2021;12(10):3045-3056
Journal of Cancer 2021;12(10):3045-3056
Cancer-associated fibroblasts in gastric cancer affect malignant progression via the CXCL12-CXCR4 axis.
Qin Y, Wang F, Ni H, Liu Y, Yin Y, Zhou X, Gao G, Li Q, Qi X, Li J
Journal of Cancer 2021;12(10):3011-3023
Journal of Cancer 2021;12(10):3011-3023
Bioengineering CXCR4-overexpressing cell membrane functionalized ROS-responsive nanotherapeutics for targeting cerebral ischemia-reperfusion injury.
Luo L, Zang G, Liu B, Qin X, Zhang Y, Chen Y, Zhang H, Wu W, Wang G
Theranostics 2021;11(16):8043-8056
Theranostics 2021;11(16):8043-8056
Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.
Ma S, Zhou J, Huang T, Zhang Z, Xing Q, Zhou X, Zhang K, Yao M, Cheng T, Wang X, Wen X, Guan F
Acta biomaterialia 2021 Sep 1;131:185-197
Acta biomaterialia 2021 Sep 1;131:185-197
CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c-Met signaling pathway.
Zhao D, Yang Z, Chen C, Zhang Z, Yu Y, Li Z
FEBS open bio 2021 Nov;11(11):3115-3125
FEBS open bio 2021 Nov;11(11):3115-3125
Vincetoxicum arnottianum modulates motility features and metastatic marker expression in pediatric rhabdomyosarcoma by stabilizing the actin cytoskeleton.
Adamus A, Ali I, Vasileiadis V, Al-Hileh L, Lisec J, Frank M, Seitz G, Engel N
BMC complementary medicine and therapies 2021 May 4;21(1):136
BMC complementary medicine and therapies 2021 May 4;21(1):136
Construction and a preliminary study of paracrine effect of bone marrow-derived endothelial progenitor cell sheet.
Xue F, Bai Y, Jiang Y, Liu J, Jian K
Cell and tissue banking 2021 May 30;
Cell and tissue banking 2021 May 30;
A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis.
Dong X, Zhang M, Chen Y, Li C, Wang Y, Jin X
Journal of plastic surgery and hand surgery 2021 Jun 10;:1-10
Journal of plastic surgery and hand surgery 2021 Jun 10;:1-10
Pretreatment with licochalcone a enhances therapeutic activity of rat bone marrow mesenchymal stem cells in animal models of colitis.
Chen M, Yu Y, Yang S, Yang D
Iranian journal of basic medical sciences 2021 Aug;24(8):1050-1057
Iranian journal of basic medical sciences 2021 Aug;24(8):1050-1057
miR-204-5p Suppress Lymph Node Metastasis via Regulating CXCL12 and CXCR4 in Gastric Cancer.
Zhang J, Xing L, Xu H, Wang K, She J, Shi F, Wu H, Sun Y, Gao J, He S
Journal of Cancer 2020;11(11):3199-3206
Journal of Cancer 2020;11(11):3199-3206
MiR-645 promotes invasiveness, metastasis and tumor growth in colorectal cancer by targeting EFNA5.
Li S, Hou X, Wu C, Han L, Li Q, Wang J, Luo S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109889
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109889
LncRNA-cCSC1 modulates cancer stem cell properties in colorectal cancer via activation of the Hedgehog signaling pathway.
Zhou H, Xiong Y, Peng L, Wang R, Zhang H, Fu Z
Journal of cellular biochemistry 2020 Mar;121(3):2510-2524
Journal of cellular biochemistry 2020 Mar;121(3):2510-2524
CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model.
Liu ZY, Song ZW, Guo SW, He JS, Wang SY, Zhu JG, Yang HL, Liu JB
CNS neuroscience & therapeutics 2019 Sep;25(9):922-936
CNS neuroscience & therapeutics 2019 Sep;25(9):922-936
N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.
Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, Wang F, Ma NF, Guan X, Yun JP, Wang FW, Xu RH, Dan Xie
Nature communications 2019 Oct 16;10(1):4695
Nature communications 2019 Oct 16;10(1):4695
Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1.
Tang Y, Lu Y, Chen Y, Luo L, Cai L, Peng B, Huang W, Liao H, Zhao L, Pan M
Journal of experimental & clinical cancer research : CR 2019 Nov 21;38(1):473
Journal of experimental & clinical cancer research : CR 2019 Nov 21;38(1):473
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Ye C, Zhang C, Huang H, Yang B, Xiao G, Kong D, Tian Q, Song Q, Song Y, Tan H, Wang Y, Zhou T, Zi X, Sun Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1/CXCR4 and mSCF/Kit-ETV1 Pathways in the Stomach of Diabetic Mice.
Zhao J, An J, Liu S
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7878053
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7878053
Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811.
Li SH, Dong WC, Fan L, Wang GS
American journal of translational research 2016;8(9):3812-3821
American journal of translational research 2016;8(9):3812-3821
The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration.
Bi J, Li P, Li C, He J, Wang Y, Zhang H, Fan X, Jia R, Ge S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Mar;37(3):4175-82
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Mar;37(3):4175-82
Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system.
Wang J, Yu L, Jiang C, Fu X, Liu X, Wang M, Ou C, Cui X, Zhou C, Wang J
Brain, behavior, and immunity 2015 Jan;43:172-83
Brain, behavior, and immunity 2015 Jan;43:172-83
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11073-2-AP(CXCR4 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CXCR4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CXCR4. This antibody recognizes human,mouse,rat antigen. The CXCR4 antibody has been validated for the following applications: ELISA, WB, IP analysis.