BS9179

antibody from Bioworld Technology, Inc
Targeting: BAG4 SODD
Provider product page for BS9179
Western blot
Immunohistochemistry

Antibody data

Product number
BS9179 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Bag 4 (V442) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 411-460 of Human Bag-4.
Description
The cytokine TNF (tumor necrosis factor) signals through the TNF-R1 receptor to activate various cellular pathways, including apoptosis and NFkB activation. TNF binding induces receptor aggregation, resulting in the recruitment of TRADD, FADD, TRAF2 and RIP to the intracellular ¡ùdeath¡ì domain of the receptor complex, which in turn activates signaling pathways including apoptosis and NFkB activation. SODD, for silencer of death domains, was found to be associated with the intracellular ¡ùdeath¡ì domain of TNF-R1 in the absence of TNF stimulation. TNF treatment results in the release of SODD from TNF-R1, allowing the recruitment of TRADD and TRAF2 to the receptor complex. Thus, SODD may play a role in preventing spontaneous signaling by death-domain receptors, in the absence of ligand.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BAG4 protein structure - BS9179 shown in red.