CABT-B9980

antibody from Creative Diagnostics

Targeting: CLCF1 BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-B9980

Provider

Creative Diagnostics

Product name

Mouse anti-Human CLCF1 monoclonal antibody, clone 8F21

Antibody type

Monoclonal

Description

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgM

Antibody clone number

8F21

Vial size

200 _l

Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.