BS7756

antibody from Bioworld Technology, Inc
Targeting: ID3 bHLHb25, HEIR-1
Provider product page for BS7756
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7756 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ID3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human ID3.
Description
Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (1ÿ3), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ID3 protein structure - BS7756 shown in red.