CABT-L596

antibody from Creative Diagnostics
Targeting: MYB c-myb
Provider product page for CABT-L596
Western blot
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
CABT-L596 - Provider product page
Provider
Creative Diagnostics
Product name
Rabbit Anti-Human MYB monoclonal antibody, clone TA15-92
Antibody type
Monoclonal
Description
The Myb family of transcription factors regulates proliferation, differentiation and apoptosis of hematopoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear and binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia and transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, and it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation and may be essential for hematopoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
TA15-92
Vial size
100 _l
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
MYB protein structure - CABT-L596 shown in red.