681001

antibody from BioLegend
Targeting: TAL1 bHLHa17, SCL, TCL5
Provider product page for 681001
Western blot
Immunocytochemistry

Antibody data

Product number
681001 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#681001, RRID:AB_2566441
Product name
Purified anti-TAL1
Antibody type
Monoclonal
Antigen
Partial human TAL1 recombinant protein (1-263 a.a.) expressed in E. coli.
Description
TAL1, also known as SCL, is a class I basic helix-loop-helix (bHLH) transcription factor. TAL1 is essential for the establishment of hematopoietic stem cells during embryogenesis, and regulating proliferation and differentiation of multiple hematopoeitic cell lineages, such as erythrocytes, megakaryocytes, mast cells, and eosinoohils. Tal1-null mice are embryonic lethal due to the failure of yolk sac hematopoiesis and vascular defects. In hematopoietic cells, TAL1 forms a multiprotein complex with other transcription factors, which include the E protein TCF3, LMO2, LDB1, and GATA family members. The large protein complex containing TAL1 binds to specific cis-regulatory elements encoding the consensus sequence AACAGATGGT and regulates expression of target genes. TAL1 is not expressed in normal lymphoid cells, but ectopic expression of TAL1 in T-cells leads to T-cell acute lymphocytic leukemia (T-ALL).
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
4G8C07
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
TAL1 protein structure - 681001 shown in red.