679502

antibody from BioLegend

Targeting: EGF

Immunoprecipitation (Data presented on provider website)

Antibody Data

Product number

679502

Provider

BioLegend

Proper citation

BioLegend Cat#679502, RRID:AB_2566190

Product name

Purified anti-EGF

Antibody type

Monoclonal

Antigen

Human EGF, amino acids Asn971 - Arg1023, with an N-terminal Met (Accession# P01133) was expressed in E. coli.

Description

Epidermal growth factor (EGF) is a small 6 kD polypeptide and has six conserved cysteine residues that form three intramolecular disulfide bonds. Human EGF is synthesized as transmembrane precursor proteins (1207 amino acids), which are proteolytically cleaved to generate the 54 amino acid mature EGF. EGF/EGF receptor signaling pathway plays an important role in proliferation, differentiation, and migration of a variety of cell types, especially in epithelial cells. The binding of EGF to EGFR induces receptor dimerization, which is required for activating the tyrosine kinase dimerization in the receptor cytoplasmic domain. In addition, the binding of EGF to its receptor triggers several signal transduction pathways including JAK/STAT, Ras/ERK/, and PI3K/AKT pathways. The blocking of the EGF/EGFR pathway can suppress some tumor cell proliferation.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

M1401E03

Vial size

100 µg

Concentration

0.5 mg/ml

Storage

2°C-8°C

Handling

Ambient RT