ADI-AAM-227-E

antibody from Enzo Life Sciences

Targeting: FAS APO-1, APT1, CD95, FAS1, TNFRSF6

Western blot (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Functional assay (Recommended by provider)

Antibody Data

Product number

ADI-AAM-227-E

Provider

Enzo Life Sciences

Proper citation

Enzo Life Sciences Cat#ADI-AAM-227-E, RRID:AB_2038981

Product name

Fas monoclonal antibody (ZB4)

Antibody type

Monoclonal

Antigen

Recombinant full length protein

Description

Protein A affinity purified.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

ZB4

Vial size

100 μg

Storage

-20°C

References

Submitted references

LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes.

DiFranco KM, Johnson-Farley N, Bertino JR, Elson D, Vega BA, Belinka BA Jr, Kachlany SC
Leukemia research 2015 Jun;39(6):649-56

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Enhanced CD95-mediated apoptosis contributes to radiation hypersensitivity of NBS lymphoblasts.

Sagan D, Mörtl S, Müller I, Eckardt-Schupp F, Eichholtz-Wirth H
Apoptosis : an international journal on programmed cell death 2007 Apr;12(4):753-67

Immunocytochemistry

Supportive validation

Submitted by

Enzo Life Sciences (provider)

Main image

Experimental details

Western blot analysis of human Fas expression in human Fas transfected cells; Lane1: anti-human Fas (ZB4), Lane2: anti-human Fas (UB2) and Lane3: anti-human Fas (CH11).

Supportive validation

Submitted by

Enzo Life Sciences (provider)

Main image

Experimental details

Flow cytometric analysis of human Fas expression on normal human lymphocytes. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of Fas mAb (ZB4) to the cells.