Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 16210-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16210-1-AP, RRID:AB_2060466
- Product name
- ASS1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ASS1 antibody (Cat. #16210-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy.
BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
ASS1 Overexpression: A Hallmark of Sonic Hedgehog Hepatocellular Adenomas; Recommendations for Clinical Practice.
An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs.
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.
Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.
Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma.
Circular RNA circASS1 is downregulated in breast cancer cells MDA-MB-231 and suppressed invasion and migration.
Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.
Androgen receptor regulates ASS1P3/miR-34a-5p/ASS1 signaling to promote renal cell carcinoma cell growth.
Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.
Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of Hugan Qingzhi on non-alcoholic fatty liver disease in rats.
CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
Novel proteomic biomarker panel for prediction of aggressive metastatic hepatocellular carcinoma relapse in surgically resectable patients.
Chu CY, Lee YC, Hsieh CH, Yeh CT, Chao TY, Chen PH, Lin IH, Hsieh TH, Shih JW, Cheng CH, Chang CC, Lin PS, Huang YL, Chen TM, Yen Y, Ann DK, Kung HJ
Theranostics 2021;11(8):3624-3641
Theranostics 2021;11(8):3624-3641
BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
Springer MZ, Poole LP, Drake LE, Bock-Hughes A, Boland ML, Smith AG, Hart J, Chourasia AH, Liu I, Bozek G, Macleod KF
Autophagy 2021 Nov;17(11):3530-3546
Autophagy 2021 Nov;17(11):3530-3546
ASS1 Overexpression: A Hallmark of Sonic Hedgehog Hepatocellular Adenomas; Recommendations for Clinical Practice.
Sala M, Gonzales D, Leste-Lasserre T, Dugot-Senant N, Paradis V, Di Tommaso S, Dupuy JW, Pitard V, Dourthe C, Sciarra A, Sempoux C, Ferrell LD, Clouston AD, Miller G, Yeh MM, Thung S, Gouw ASH, Quaglia A, Han J, Huan J, Fan C, Crawford J, Nakanuma Y, Harada K, le Bail B, Castain C, Frulio N, Trillaud H, Possenti L, Blanc JF, Chiche L, Laurent C, Balabaud C, Bioulac-Sage P, Raymond AA, Saltel F
Hepatology communications 2020 Jun;4(6):809-824
Hepatology communications 2020 Jun;4(6):809-824
An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs.
Li WJ, Zhu XJ, Yuan TJ, Wang ZY, Bian ZQ, Jing HS, Shi X, Chen CY, Fu GB, Huang WJ, Shi YP, Liu Q, Zeng M, Zhang HD, Wu HP, Yu WF, Zhai B, Yan HX
Science translational medicine 2020 Jul 8;12(551)
Science translational medicine 2020 Jul 8;12(551)
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H
Immunity 2020 Jul 14;53(1):204-216.e10
Immunity 2020 Jul 14;53(1):204-216.e10
SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.
Zhang W, Dong Z, Xu M, Zhang S, Liu C, Chen S
Molecular metabolism 2020 Feb;32:85-96
Molecular metabolism 2020 Feb;32:85-96
Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.
Cao Y, Ding W, Zhang J, Gao Q, Yang H, Cao W, Wang Z, Fang L, Du R
Journal of proteome research 2019 May 3;18(5):2032-2044
Journal of proteome research 2019 May 3;18(5):2032-2044
Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma.
Tao X, Zuo Q, Ruan H, Wang H, Jin H, Cheng Z, Lv Y, Qin W, Wang C
Acta biochimica et biophysica Sinica 2019 Mar 1;51(3):263-276
Acta biochimica et biophysica Sinica 2019 Mar 1;51(3):263-276
Circular RNA circASS1 is downregulated in breast cancer cells MDA-MB-231 and suppressed invasion and migration.
Hou JC, Xu Z, Zhong SL, Zhang HD, Jiang LH, Chen X, Zhu LP, Li J, Zhou SY, Yang SJ, He YJ, Wang DD, Deng F, Zhang Q, Wang JY, Hu JH, Zhang W, Wu Y, Ding L, Zhao JH, Tang JH
Epigenomics 2019 Feb;11(2):199-213
Epigenomics 2019 Feb;11(2):199-213
Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.
Hong R, Zhang W, Xia X, Zhang K, Wang Y, Wu M, Fan J, Li J, Xia W, Xu F, Chen J, Wang S, Zhan Q
Molecular oncology 2019 Apr;13(4):959-977
Molecular oncology 2019 Apr;13(4):959-977
Androgen receptor regulates ASS1P3/miR-34a-5p/ASS1 signaling to promote renal cell carcinoma cell growth.
Wang K, Sun Y, Guo C, Liu T, Fei X, Chang C
Cell death & disease 2019 Apr 18;10(5):339
Cell death & disease 2019 Apr 18;10(5):339
Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.
Marable SS, Chung E, Adam M, Potter SS, Park JS
JCI insight 2018 Jul 26;3(14)
JCI insight 2018 Jul 26;3(14)
Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of Hugan Qingzhi on non-alcoholic fatty liver disease in rats.
Yao X, Xia F, Tang W, Xiao C, Yang M, Zhou B
Journal of ethnopharmacology 2018 Feb 15;212:208-215
Journal of ethnopharmacology 2018 Feb 15;212:208-215
CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.
Lin R, Mo Y, Zha H, Qu Z, Xie P, Zhu ZJ, Xu Y, Xiong Y, Guan KL
Molecular cell 2017 Oct 5;68(1):198-209.e6
Molecular cell 2017 Oct 5;68(1):198-209.e6
Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients.
Qin S, Zhou Y, Gray L, Kusebauch U, McEvoy L, Antoine DJ, Hampson L, Park KB, Campbell D, Caballero J, Glusman G, Yan X, Kim TK, Yuan Y, Wang K, Rowen L, Moritz RL, Omenn GS, Pirmohamed M, Hood L
Journal of proteome research 2016 Oct 7;15(10):3724-3740
Journal of proteome research 2016 Oct 7;15(10):3724-3740
Novel proteomic biomarker panel for prediction of aggressive metastatic hepatocellular carcinoma relapse in surgically resectable patients.
Tan GS, Lim KH, Tan HT, Khoo ML, Tan SH, Toh HC, Ching Ming Chung M
Journal of proteome research 2014 Nov 7;13(11):4833-46
Journal of proteome research 2014 Nov 7;13(11):4833-46
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 16210-1-AP(ASS1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 16210-1-AP(ASS1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ASS1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ASS1. This antibody recognizes human,mouse,rat antigen. The ASS1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.