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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [91]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
- Flow cytometry [2]
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- Product number
- NB300-146 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB300-146, RRID:AB_2060979
- Product name
- Mouse Monoclonal Sodium Potassium ATPase Alpha 1 Antibody
- Antibody type
- Monoclonal
- Description
- Unpurified. This is specific for Na,K-ATPase alpha 1 subunit.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Drosophila, Guinea Pig, Porcine, Rabbit, Sheep, Simian, Xenopus, Yeast
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.05 ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references "Reversed polarization" of Na/K-ATPase-a sign of inverted transport in the human endolymphatic sac: a super-resolution structured illumination microscopy (SR-SIM) study.
Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases.
The commensal bacterium Bacteroides fragilis down-regulates ferroportin expression and alters iron homeostasis in macrophages.
Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
Expression of Na/K-ATPase subunits in the human cochlea: a confocal and super-resolution microscopy study with special reference to auditory nerve excitation and cochlear implantation.
The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.
Choroid plexus glutathione peroxidases are instrumental in protecting the brain fluid environment from hydroperoxides during postnatal development.
An FRMD4B variant suppresses dysplastic photoreceptor lesions in models of enhanced S-cone syndrome and of Nrl deficiency.
A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells.
Corneal Endothelial Regeneration Using Mesenchymal Stem Cells Derived from Human Umbilical Cord.
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration.
Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells.
Activation of liver X receptor inhibits OCT2-mediated organic cation transport in renal proximal tubular cells.
Astrocyte-mediated infantile-onset leukoencephalopathy mouse model.
In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland.
A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells.
The Apical Localization of Na(+), K(+)-ATPase in Cultured Human Retinal Pigment Epithelial Cells Depends on Expression of the β(2) Subunit.
T-Lymphocytes Traffic into the Brain across the Blood-CSF Barrier: Evidence Using a Reconstituted Choroid Plexus Epithelium.
Inhomogeneity Based Characterization of Distribution Patterns on the Plasma Membrane.
Super-resolution structured illumination fluorescence microscopy of the lateral wall of the cochlea: the Connexin26/30 proteins are separately expressed in man.
Endothelin Receptor A Antagonism and Fetal Growth in Endothelial Nitric Oxide Synthase Gene Knockout Maternal and Fetal Mice.
Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy.
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.
Effects of Hydrostatic Pressure on Carcinogenic Properties of Epithelia.
Wfs1-deficient animals have brain-region-specific changes of Na+, K+-ATPase activity and mRNA expression of α1 and β1 subunits.
Proteomic Analysis of Isolated Plasma Membrane Fractions from the Mammary Gland in Lactating Cows.
Impaired insulin signaling affects renal organic anion transporter 3 (Oat3) function in streptozotocin-induced diabetic rats.
Midkine, a potential link between obesity and insulin resistance.
Protective effects of dexamethasone on early acute lung injury induced by oleic acid in rats.
Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex.
Cholera toxin enhances Na(+) absorption across MCF10A human mammary epithelia.
Antioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kützing extract in experimental type 2 diabetic rats.
Proteomic profiling and pathway analysis of the response of rat renal proximal convoluted tubules to metabolic acidosis.
Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.
VHL-dependent regulation of a β-dystroglycan glycoform and glycogene expression in renal cancer.
N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells.
Validation of Na,K-ATPase pump function of corneal endothelial cells for corneal regenerative medicine.
Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury.
Activation of liver X receptors reduces CFTR-mediated Cl(-) transport in kidney collecting duct cells.
Statin upregulates the expression of klotho, an anti-aging gene, in experimental cyclosporine nephropathy.
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.
Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.
Extracellular matrix lumican promotes bacterial phagocytosis, and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity.
Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.
Characterization of the lipid droplet proteome of a clonal insulin-producing β-cell line (INS-1 832/13).
Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization.
A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes.
Insulin down-regulates specific activity of ATP-binding cassette transporter A1 for high density lipoprotein biogenesis through its specific phosphorylation.
Critical role for CD38-mediated Ca2+ signaling in thrombin-induced procoagulant activity of mouse platelets and hemostasis.
Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.
Polyamine pathway contributes to the pathogenesis of Parkinson disease.
Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP.
Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis.
Development and validation of a novel protein extraction methodology for quantitation of protein expression in formalin-fixed paraffin-embedded tissues using western blotting.
Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes.
Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers.
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.
Low levels of Na, K-ATPase and carbonic anhydrase II during choroid plexus development suggest limited involvement in early CSF secretion.
Na+-glucose cotransporter is also expressed in mesothelium of species with thick visceral pleura.
Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling.
ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Evolutionarily conserved gene family important for fat storage.
Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization.
Lipid rafts are required for Kit survival and proliferation signals.
Expression of Na+-glucose cotransporter (SGLT1) in visceral and parietal mesothelium of rabbit pleura.
Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.
Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice.
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins.
PACSIN3 overexpression increases adipocyte glucose transport through GLUT1.
The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation.
Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration.
Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms.
A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport.
Effects of ACE inhibition on proximal tubule sodium transport.
FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts.
A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function.
Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi blockade mechanism.
Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake.
Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells.
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.
Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance.
All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides.
18O-exchange evidence that mutations of arginine in a signature sequence for P-type pumps affect inorganic phosphate binding.
18O-exchange evidence that mutations of arginine in a signature sequence for P-type pumps affect inorganic phosphate binding.
Proximal tubule Na transporter responses are the same during acute and chronic hypertension.
In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition.
Reversible effects of acute hypertension on proximal tubule sodium transporters.
Reversible effects of acute hypertension on proximal tubule sodium transporters.
Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes.
Nordström CK, Danckwardt-Lillieström N, Liu W, Rask-Andersen H
Cell and tissue research 2020 Mar;379(3):445-457
Cell and tissue research 2020 Mar;379(3):445-457
Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases.
O'Banion CP, Vickerman BM, Haar L, Lawrence DS
Cell chemical biology 2019 Oct 17;26(10):1393-1406.e7
Cell chemical biology 2019 Oct 17;26(10):1393-1406.e7
The commensal bacterium Bacteroides fragilis down-regulates ferroportin expression and alters iron homeostasis in macrophages.
Verma S, Prescott R, Cherayil BJ
Journal of leukocyte biology 2019 Nov;106(5):1079-1088
Journal of leukocyte biology 2019 Nov;106(5):1079-1088
Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
Rasiah PK, Maddala R, Bennett V, Rao PV
Developmental biology 2019 Feb 1;446(1):119-131
Developmental biology 2019 Feb 1;446(1):119-131
Expression of Na/K-ATPase subunits in the human cochlea: a confocal and super-resolution microscopy study with special reference to auditory nerve excitation and cochlear implantation.
Liu W, Luque M, Glueckert R, Danckwardt-Lillieström N, Nordström CK, Schrott-Fischer A, Rask-Andersen H
Upsala journal of medical sciences 2019 Aug;124(3):168-179
Upsala journal of medical sciences 2019 Aug;124(3):168-179
The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.
Deng M, Tang Y, Li W, Wang X, Zhang R, Zhang X, Zhao X, Liu J, Tang C, Liu Z, Huang Y, Peng H, Xiao L, Tang D, Scott MJ, Wang Q, Liu J, Xiao X, Watkins S, Li J, Yang H, Wang H, Chen F, Tracey KJ, Billiar TR, Lu B
Immunity 2018 Oct 16;49(4):740-753.e7
Immunity 2018 Oct 16;49(4):740-753.e7
Choroid plexus glutathione peroxidases are instrumental in protecting the brain fluid environment from hydroperoxides during postnatal development.
Saudrais E, Strazielle N, Ghersi-Egea JF
American journal of physiology. Cell physiology 2018 Oct 1;315(4):C445-C456
American journal of physiology. Cell physiology 2018 Oct 1;315(4):C445-C456
An FRMD4B variant suppresses dysplastic photoreceptor lesions in models of enhanced S-cone syndrome and of Nrl deficiency.
Kong Y, Zhao L, Charette JR, Hicks WL, Stone L, Nishina PM, Naggert JK
Human molecular genetics 2018 Oct 1;27(19):3340-3352
Human molecular genetics 2018 Oct 1;27(19):3340-3352
A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells.
Yamashita K, Hatou S, Inagaki E, Higa K, Tsubota K, Shimmura S
Scientific reports 2018 Nov 15;8(1):16868
Scientific reports 2018 Nov 15;8(1):16868
Corneal Endothelial Regeneration Using Mesenchymal Stem Cells Derived from Human Umbilical Cord.
Yamashita K, Inagaki E, Hatou S, Higa K, Ogawa A, Miyashita H, Tsubota K, Shimmura S
Stem cells and development 2018 Aug 15;27(16):1097-1108
Stem cells and development 2018 Aug 15;27(16):1097-1108
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration.
Geng Z, Walsh PJ, Truong V, Hill C, Ebeling M, Kapphahn RJ, Montezuma SR, Yuan C, Roehrich H, Ferrington DA, Dutton JR
PloS one 2017;12(3):e0173575
PloS one 2017;12(3):e0173575
Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells.
Kavanagh EL, Lindsay S, Halasz M, Gubbins LC, Weiner-Gorzel K, Guang MHZ, McGoldrick A, Collins E, Henry M, Blanco-Fernández A, O Gorman P, Fitzpatrick P, Higgins MJ, Dowling P, McCann A
Oncogenesis 2017 Oct 9;6(10):e388
Oncogenesis 2017 Oct 9;6(10):e388
Activation of liver X receptor inhibits OCT2-mediated organic cation transport in renal proximal tubular cells.
Wongwan T, Kittayaruksakul S, Asavapanumas N, Chatsudthipong V, Soodvilai S
Pflugers Archiv : European journal of physiology 2017 Nov;469(11):1471-1481
Pflugers Archiv : European journal of physiology 2017 Nov;469(11):1471-1481
Astrocyte-mediated infantile-onset leukoencephalopathy mouse model.
Sugio S, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M, Fukata M, Ikenaka K, Tanaka KF
Glia 2017 Jan;65(1):150-168
Glia 2017 Jan;65(1):150-168
In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland.
Ontsouka CE, Huang X, Aliyev E, Albrecht C
Molecular and cellular endocrinology 2017 Jan 5;439:35-45
Molecular and cellular endocrinology 2017 Jan 5;439:35-45
A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells.
Uchida H, Machida M, Miura T, Kawasaki T, Okazaki T, Sasaki K, Sakamoto S, Ohuchi N, Kasahara M, Umezawa A, Akutsu H
JCI insight 2017 Jan 12;2(1):e86492
JCI insight 2017 Jan 12;2(1):e86492
The Apical Localization of Na(+), K(+)-ATPase in Cultured Human Retinal Pigment Epithelial Cells Depends on Expression of the β(2) Subunit.
Lobato-Álvarez JA, Roldán ML, López-Murillo TD, González-Ramírez R, Bonilla-Delgado J, Shoshani L
Frontiers in physiology 2016;7:450
Frontiers in physiology 2016;7:450
T-Lymphocytes Traffic into the Brain across the Blood-CSF Barrier: Evidence Using a Reconstituted Choroid Plexus Epithelium.
Strazielle N, Creidy R, Malcus C, Boucraut J, Ghersi-Egea JF
PloS one 2016;11(3):e0150945
PloS one 2016;11(3):e0150945
Inhomogeneity Based Characterization of Distribution Patterns on the Plasma Membrane.
Paparelli L, Corthout N, Pavie B, Wakefield DL, Sannerud R, Jovanovic-Talisman T, Annaert W, Munck S
PLoS computational biology 2016 Sep;12(9):e1005095
PLoS computational biology 2016 Sep;12(9):e1005095
Super-resolution structured illumination fluorescence microscopy of the lateral wall of the cochlea: the Connexin26/30 proteins are separately expressed in man.
Liu W, Edin F, Blom H, Magnusson P, Schrott-Fischer A, Glueckert R, Santi PA, Li H, Laurell G, Rask-Andersen H
Cell and tissue research 2016 Jul;365(1):13-27
Cell and tissue research 2016 Jul;365(1):13-27
Endothelin Receptor A Antagonism and Fetal Growth in Endothelial Nitric Oxide Synthase Gene Knockout Maternal and Fetal Mice.
Luo K, Thaete LG, Neerhof MG
Reproductive sciences (Thousand Oaks, Calif.) 2016 Aug;23(8):1028-36
Reproductive sciences (Thousand Oaks, Calif.) 2016 Aug;23(8):1028-36
Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy.
Jiang Y, Woosley AN, Sivalingam N, Natarajan S, Howe PH
Nature cell biology 2016 Aug;18(8):851-63
Nature cell biology 2016 Aug;18(8):851-63
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.
Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z
Nature medicine 2016 Apr;22(4):421-6
Nature medicine 2016 Apr;22(4):421-6
Effects of Hydrostatic Pressure on Carcinogenic Properties of Epithelia.
Tokuda S, Kim YH, Matsumoto H, Muro S, Hirai T, Mishima M, Furuse M
PloS one 2015;10(12):e0145522
PloS one 2015;10(12):e0145522
Wfs1-deficient animals have brain-region-specific changes of Na+, K+-ATPase activity and mRNA expression of α1 and β1 subunits.
Sütt S, Altpere A, Reimets R, Visnapuu T, Loomets M, Raud S, Salum T, Mahlapuu R, Kairane C, Zilmer M, Vasar E
Journal of neuroscience research 2015 Mar;93(3):530-7
Journal of neuroscience research 2015 Mar;93(3):530-7
Proteomic Analysis of Isolated Plasma Membrane Fractions from the Mammary Gland in Lactating Cows.
Yan Q, Tang S, Tan Z, Han X, Zhou C, Kang J, Wang M
Journal of agricultural and food chemistry 2015 Aug 26;63(33):7388-98
Journal of agricultural and food chemistry 2015 Aug 26;63(33):7388-98
Impaired insulin signaling affects renal organic anion transporter 3 (Oat3) function in streptozotocin-induced diabetic rats.
Lungkaphin A, Arjinajarn P, Pongchaidecha A, Srimaroeng C, Chatsudthipong L, Chatsudthipong V
PloS one 2014;9(5):e96236
PloS one 2014;9(5):e96236
Midkine, a potential link between obesity and insulin resistance.
Fan N, Sun H, Wang Y, Zhang L, Xia Z, Peng L, Hou Y, Shen W, Liu R, Peng Y
PloS one 2014;9(2):e88299
PloS one 2014;9(2):e88299
Protective effects of dexamethasone on early acute lung injury induced by oleic acid in rats.
Huang B, Wang DX, Deng W
International journal of clinical and experimental medicine 2014;7(12):4698-709
International journal of clinical and experimental medicine 2014;7(12):4698-709
Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex.
Ohtake N, Saito M, Eto M, Seki K
Regulatory peptides 2014 May;190-191:1-11
Regulatory peptides 2014 May;190-191:1-11
Cholera toxin enhances Na(+) absorption across MCF10A human mammary epithelia.
Wang Q, Schultz BD
American journal of physiology. Cell physiology 2014 Mar 1;306(5):C471-84
American journal of physiology. Cell physiology 2014 Mar 1;306(5):C471-84
Antioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kützing extract in experimental type 2 diabetic rats.
Ontawong A, Saowakon N, Vivithanaporn P, Pongchaidecha A, Lailerd N, Amornlerdpison D, Lungkaphin A, Srimaroeng C
BioMed research international 2013;2013:820786
BioMed research international 2013;2013:820786
Proteomic profiling and pathway analysis of the response of rat renal proximal convoluted tubules to metabolic acidosis.
Schauer KL, Freund DM, Prenni JE, Curthoys NP
American journal of physiology. Renal physiology 2013 Sep 1;305(5):F628-40
American journal of physiology. Renal physiology 2013 Sep 1;305(5):F628-40
Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.
Drivas TG, Holzbaur EL, Bennett J
The Journal of clinical investigation 2013 Oct;123(10):4525-39
The Journal of clinical investigation 2013 Oct;123(10):4525-39
VHL-dependent regulation of a β-dystroglycan glycoform and glycogene expression in renal cancer.
Aggelis V, Craven RA, Peng J, Harnden P, Schaffer L, Hernandez GE, Head SR, Maher ER, Tonge R, Selby PJ, Banks RE
International journal of oncology 2013 Nov;43(5):1368-76
International journal of oncology 2013 Nov;43(5):1368-76
N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells.
Feduska JM, Garcia PL, Brennan SB, Bu S, Council LN, Yoon KJ
BMC cancer 2013 May 28;13:261
BMC cancer 2013 May 28;13:261
Validation of Na,K-ATPase pump function of corneal endothelial cells for corneal regenerative medicine.
Hatou S, Higa K, Inagaki E, Yoshida S, Kimura E, Hayashi R, Tsujikawa M, Tsubota K, Nishida K, Shimmura S
Tissue engineering. Part C, Methods 2013 Dec;19(12):901-10
Tissue engineering. Part C, Methods 2013 Dec;19(12):901-10
Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury.
Jang HS, Han SJ, Kim JI, Lee S, Lipschutz JH, Park KM
Biochimica et biophysica acta 2013 Dec;1832(12):1998-2008
Biochimica et biophysica acta 2013 Dec;1832(12):1998-2008
Activation of liver X receptors reduces CFTR-mediated Cl(-) transport in kidney collecting duct cells.
Raksaseri P, Chatsudthipong V, Muanprasat C, Soodvilai S
American journal of physiology. Renal physiology 2013 Aug 15;305(4):F583-91
American journal of physiology. Renal physiology 2013 Aug 15;305(4):F583-91
Statin upregulates the expression of klotho, an anti-aging gene, in experimental cyclosporine nephropathy.
Yoon HE, Lim SW, Piao SG, Song JH, Kim J, Yang CW
Nephron. Experimental nephrology 2012;120(4):e123-33
Nephron. Experimental nephrology 2012;120(4):e123-33
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.
Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken P
Neuron 2012 Sep 20;75(6):1008-21
Neuron 2012 Sep 20;75(6):1008-21
Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.
Desmoulin SK, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH
Molecular pharmacology 2012 Oct;82(4):591-600
Molecular pharmacology 2012 Oct;82(4):591-600
Extracellular matrix lumican promotes bacterial phagocytosis, and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity.
Shao H, Lee S, Gae-Scott S, Nakata C, Chen S, Hamad AR, Chakravarti S
The Journal of biological chemistry 2012 Oct 19;287(43):35860-72
The Journal of biological chemistry 2012 Oct 19;287(43):35860-72
Anti-apoptotic role of caspase-cleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling.
Le Goff A, Ji Z, Leclercq B, Bourette RP, Mougel A, Guerardel C, de Launoit Y, Vicogne J, Goormachtigh G, Fafeur V
The Journal of biological chemistry 2012 Oct 12;287(42):35382-96
The Journal of biological chemistry 2012 Oct 12;287(42):35382-96
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.
Garg AD, Krysko DV, Verfaillie T, Kaczmarek A, Ferreira GB, Marysael T, Rubio N, Firczuk M, Mathieu C, Roebroek AJ, Annaert W, Golab J, de Witte P, Vandenabeele P, Agostinis P
The EMBO journal 2012 Mar 7;31(5):1062-79
The EMBO journal 2012 Mar 7;31(5):1062-79
Characterization of the lipid droplet proteome of a clonal insulin-producing β-cell line (INS-1 832/13).
Larsson S, Resjö S, Gomez MF, James P, Holm C
Journal of proteome research 2012 Feb 3;11(2):1264-73
Journal of proteome research 2012 Feb 3;11(2):1264-73
Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization.
Chun KH, Araki K, Jee Y, Lee DH, Oh BC, Huang H, Park KS, Lee SW, Zabolotny JM, Kim YB
Endocrinology 2012 Apr;153(4):1649-62
Endocrinology 2012 Apr;153(4):1649-62
A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes.
Thimiri Govinda Raj DB, Ghesquière B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, Annaert W
Molecular systems biology 2011 Oct 25;7:541
Molecular systems biology 2011 Oct 25;7:541
Insulin down-regulates specific activity of ATP-binding cassette transporter A1 for high density lipoprotein biogenesis through its specific phosphorylation.
Nonomura K, Arai Y, Mitani H, Abe-Dohmae S, Yokoyama S
Atherosclerosis 2011 Jun;216(2):334-41
Atherosclerosis 2011 Jun;216(2):334-41
Critical role for CD38-mediated Ca2+ signaling in thrombin-induced procoagulant activity of mouse platelets and hemostasis.
Mushtaq M, Nam TS, Kim UH
The Journal of biological chemistry 2011 Apr 15;286(15):12952-8
The Journal of biological chemistry 2011 Apr 15;286(15):12952-8
Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7.
Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S
Journal of lipid research 2010 Sep;51(9):2591-9
Journal of lipid research 2010 Sep;51(9):2591-9
Polyamine pathway contributes to the pathogenesis of Parkinson disease.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JP, Ringe D, Cote L, Lindquist S, Masliah E, Petsko GA, Marder K, Clark LN, Small SA
Proceedings of the National Academy of Sciences of the United States of America 2010 Sep 28;107(39):16970-5
Proceedings of the National Academy of Sciences of the United States of America 2010 Sep 28;107(39):16970-5
Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP.
Zhang Y, Liu R, Ni M, Gill P, Lee AS
The Journal of biological chemistry 2010 May 14;285(20):15065-75
The Journal of biological chemistry 2010 May 14;285(20):15065-75
Altered ion transport by thyroid epithelia from CFTR(-/-) pigs suggests mechanisms for hypothyroidism in cystic fibrosis.
Li H, Ganta S, Fong P
Experimental physiology 2010 Dec;95(12):1132-44
Experimental physiology 2010 Dec;95(12):1132-44
Development and validation of a novel protein extraction methodology for quantitation of protein expression in formalin-fixed paraffin-embedded tissues using western blotting.
Nirmalan NJ, Harnden P, Selby PJ, Banks RE
The Journal of pathology 2009 Mar;217(4):497-506
The Journal of pathology 2009 Mar;217(4):497-506
Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes.
Feldmann A, Winterstein C, White R, Trotter J, Krämer-Albers EM
Journal of neuroscience research 2009 Jun;87(8):1760-72
Journal of neuroscience research 2009 Jun;87(8):1760-72
Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers.
Peyrottes I, Navarro V, Ondo-Mendez A, Marcellin D, Bellanger L, Marsault R, Lindenthal S, Ettore F, Darcourt J, Pourcher T
European journal of endocrinology 2009 Feb;160(2):215-25
European journal of endocrinology 2009 Feb;160(2):215-25
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.
Cottrell GS, Padilla BE, Amadesi S, Poole DP, Murphy JE, Hardt M, Roosterman D, Steinhoff M, Bunnett NW
The Journal of biological chemistry 2009 Aug 14;284(33):22411-25
The Journal of biological chemistry 2009 Aug 14;284(33):22411-25
Low levels of Na, K-ATPase and carbonic anhydrase II during choroid plexus development suggest limited involvement in early CSF secretion.
Johansson P, Dziegielewska K, Saunders N
Neuroscience letters 2008 Sep 5;442(1):77-80
Neuroscience letters 2008 Sep 5;442(1):77-80
Na+-glucose cotransporter is also expressed in mesothelium of species with thick visceral pleura.
Sironi C, Bodega F, Porta C, Monaco A, Zocchi L, Agostoni E
Respiratory physiology & neurobiology 2008 May 31;161(3):261-6
Respiratory physiology & neurobiology 2008 May 31;161(3):261-6
Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling.
Winterstein C, Trotter J, Krämer-Albers EM
Journal of cell science 2008 Mar 15;121(Pt 6):834-42
Journal of cell science 2008 Mar 15;121(Pt 6):834-42
ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Burgess BL, Parkinson PF, Racke MM, Hirsch-Reinshagen V, Fan J, Wong C, Stukas S, Theroux L, Chan JY, Donkin J, Wilkinson A, Balik D, Christie B, Poirier J, Lütjohann D, Demattos RB, Wellington CL
Journal of lipid research 2008 Jun;49(6):1254-67
Journal of lipid research 2008 Jun;49(6):1254-67
Evolutionarily conserved gene family important for fat storage.
Kadereit B, Kumar P, Wang WJ, Miranda D, Snapp EL, Severina N, Torregroza I, Evans T, Silver DL
Proceedings of the National Academy of Sciences of the United States of America 2008 Jan 8;105(1):94-9
Proceedings of the National Academy of Sciences of the United States of America 2008 Jan 8;105(1):94-9
Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization.
Dayem M, Basquin C, Navarro V, Carrier P, Marsault R, Chang P, Huc S, Darrouzet E, Lindenthal S, Pourcher T
The Journal of endocrinology 2008 Apr;197(1):95-109
The Journal of endocrinology 2008 Apr;197(1):95-109
Lipid rafts are required for Kit survival and proliferation signals.
Jahn T, Leifheit E, Gooch S, Sindhu S, Weinberg K
Blood 2007 Sep 15;110(6):1739-47
Blood 2007 Sep 15;110(6):1739-47
Expression of Na+-glucose cotransporter (SGLT1) in visceral and parietal mesothelium of rabbit pleura.
Sironi C, Bodega F, Porta C, Zocchi L, Agostoni E
Respiratory physiology & neurobiology 2007 Oct 15;159(1):68-75
Respiratory physiology & neurobiology 2007 Oct 15;159(1):68-75
Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Krämer-Albers EM, Bretz N, Tenzer S, Winterstein C, Möbius W, Berger H, Nave KA, Schild H, Trotter J
Proteomics. Clinical applications 2007 Nov;1(11):1446-61
Proteomics. Clinical applications 2007 Nov;1(11):1446-61
The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.
Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, McIsaac S, Bromley K, Song W, Yang HC, Wang N, DeMattos RB, Wellington CL
Journal of lipid research 2007 May;48(5):1022-34
Journal of lipid research 2007 May;48(5):1022-34
Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice.
Qu S, Perdomo G, Su D, D'Souza FM, Shachter NS, Dong HH
Journal of lipid research 2007 Jul;48(7):1476-87
Journal of lipid research 2007 Jul;48(7):1476-87
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins.
Padilla BE, Cottrell GS, Roosterman D, Pikios S, Muller L, Steinhoff M, Bunnett NW
The Journal of cell biology 2007 Dec 3;179(5):981-97
The Journal of cell biology 2007 Dec 3;179(5):981-97
PACSIN3 overexpression increases adipocyte glucose transport through GLUT1.
Roach W, Plomann M
Biochemical and biophysical research communications 2007 Apr 13;355(3):745-50
Biochemical and biophysical research communications 2007 Apr 13;355(3):745-50
The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation.
Pessach I, Shmelzer Z, Leto TL, Dinauer MC, Levy R
Journal of leukocyte biology 2006 Sep;80(3):630-9
Journal of leukocyte biology 2006 Sep;80(3):630-9
Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration.
Chen P, Guzman JP, Leong PK, Yang LE, Perianayagam A, Babilonia E, Ho JS, Youn JH, Wang WH, McDonough AA
American journal of physiology. Cell physiology 2006 May;290(5):C1355-63
American journal of physiology. Cell physiology 2006 May;290(5):C1355-63
Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms.
Tarn C, Skorobogatko YV, Taguchi T, Eisenberg B, von Mehren M, Godwin AK
Cancer research 2006 May 15;66(10):5477-86
Cancer research 2006 May 15;66(10):5477-86
A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport.
Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB
The Journal of biological chemistry 2006 Dec 8;281(49):38071-9
The Journal of biological chemistry 2006 Dec 8;281(49):38071-9
Effects of ACE inhibition on proximal tubule sodium transport.
Leong PK, Devillez A, Sandberg MB, Yang LE, Yip DK, Klein JB, McDonough AA
American journal of physiology. Renal physiology 2006 Apr;290(4):F854-63
American journal of physiology. Renal physiology 2006 Apr;290(4):F854-63
FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts.
Pohl J, Ring A, Korkmaz U, Ehehalt R, Stremmel W
Molecular biology of the cell 2005 Jan;16(1):24-31
Molecular biology of the cell 2005 Jan;16(1):24-31
A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function.
Cross WR, Eardley I, Leese HJ, Southgate J
American journal of physiology. Renal physiology 2005 Aug;289(2):F459-68
American journal of physiology. Renal physiology 2005 Aug;289(2):F459-68
Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi blockade mechanism.
Shah M, Patel K, Sehgal PB
American journal of physiology. Cell physiology 2005 Apr;288(4):C850-62
American journal of physiology. Cell physiology 2005 Apr;288(4):C850-62
Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake.
Knox CD, Belous AE, Pierce JM, Wakata A, Nicoud IB, Anderson CD, Pinson CW, Chari RS
American journal of physiology. Gastrointestinal and liver physiology 2004 Sep;287(3):G533-40
American journal of physiology. Gastrointestinal and liver physiology 2004 Sep;287(3):G533-40
Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells.
Holzer AK, Katano K, Klomp LW, Howell SB
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Oct 1;10(19):6744-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Oct 1;10(19):6744-9
Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.
Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, Samuni AM, Felici A, Reiss M, Yarkoni S, Sowers A, Mitchell JB, Roberts AB, Russo A
The Journal of biological chemistry 2004 Apr 9;279(15):15167-76
The Journal of biological chemistry 2004 Apr 9;279(15):15167-76
Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance.
Yang LE, Zhong H, Leong PK, Perianayagam A, Campese VM, McDonough AA
American journal of physiology. Renal physiology 2003 May;284(5):F1056-65
American journal of physiology. Renal physiology 2003 May;284(5):F1056-65
All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides.
Wang J, Velotta JB, McDonough AA, Farley RA
American journal of physiology. Cell physiology 2001 Oct;281(4):C1336-43
American journal of physiology. Cell physiology 2001 Oct;281(4):C1336-43
18O-exchange evidence that mutations of arginine in a signature sequence for P-type pumps affect inorganic phosphate binding.
Farley RA, Elquza E, Müller-Ehmsen J, Kane DJ, Nagy AK, Kasho VN, Faller LD
Biochemistry 2001 May 29;40(21):6361-70
Biochemistry 2001 May 29;40(21):6361-70
18O-exchange evidence that mutations of arginine in a signature sequence for P-type pumps affect inorganic phosphate binding.
Farley RA, Elquza E, Müller-Ehmsen J, Kane DJ, Nagy AK, Kasho VN, Faller LD
Biochemistry 2001 May 29;40(21):6361-70
Biochemistry 2001 May 29;40(21):6361-70
Proximal tubule Na transporter responses are the same during acute and chronic hypertension.
Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough AA
American journal of physiology. Renal physiology 2000 Aug;279(2):F358-69
American journal of physiology. Renal physiology 2000 Aug;279(2):F358-69
In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition.
Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA
The American journal of physiology 1999 May;276(5):F711-9
The American journal of physiology 1999 May;276(5):F711-9
Reversible effects of acute hypertension on proximal tubule sodium transporters.
Zhang Y, Magyar CE, Norian JM, Holstein-Rathlou NH, Mircheff AK, McDonough AA
The American journal of physiology 1998 Apr;274(4):C1090-100
The American journal of physiology 1998 Apr;274(4):C1090-100
Reversible effects of acute hypertension on proximal tubule sodium transporters.
Zhang Y, Magyar CE, Norian JM, Holstein-Rathlou NH, Mircheff AK, McDonough AA
The American journal of physiology 1998 Apr;274(4 Pt 1):C1090-100
The American journal of physiology 1998 Apr;274(4 Pt 1):C1090-100
Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes.
McDonough AA, Zhang Y, Shin V, Frank JS
The American journal of physiology 1996 Apr;270(4 Pt 1):C1221-7
The American journal of physiology 1996 Apr;270(4 Pt 1):C1221-7
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Sodium Potassium ATPase Alpha 1 Antibody (464.6) [NB300-146] - Analysis detecting Na, K-ATPase (alpha) in porcine proximal tubule protein.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: Sodium Potassium ATPase Alpha 1 Antibody (464.6) [NB300-146] - Staining of human enodmetrial glands within the uterus using NB300-146. Note the absence of staining in the surrounding myometrial smooth muscle.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: Sodium Potassium ATPase Alpha 1 Antibody (464.6) [NB300-146] - An intracellular stain was performed on A549 cells with - Purified NBP2-61137 and a matched isotype control. Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature, followed by mouse F(ab)2 IgG (H+L) APC-conjugated secondary antibody (F0101B, R&D Systems). Image using the Purified form of this antibody.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: Sodium Potassium ATPase Alpha 1 Antibody (464.6) [NB300-146] - An intracellular stain was performed on A549 cells with NBP2-61137AF647 (Blue) and a matched isotype control (Orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 647. Image using the Alexa Fluor 647 form of this antibody.
