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- Antibody Data
- Antigen structure
- References [31]
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- Product number
- 66122-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Rac1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated RAC1 antibody (Cat. #66122-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4A4B11
- Vial size
- 20ul, 150ul
Submitted references Spatiotemporal dynamics exhibited by horizontal basal cells reveal a pro-neurogenic pathway during injury-induced olfactory epithelium regeneration.
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape.
Caffeic acid phenethyl ester ameliorates titanium particle-induced bone loss and inflammatory reaction in a mouse acute model.
Long Noncoding RNA AC078850.1 Induces NLRP3 Inflammasome-Mediated Pyroptosis in Atherosclerosis by Upregulating ITGB2 Transcription via Transcription Factor HIF-1α.
DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells.
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Single-cell RNA sequencing of CSF reveals neuroprotective RAC1(+) NK cells in Parkinson's disease.
New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1.
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion.
SYTL5 Promotes Papillary Thyroid Carcinoma Progression by Enhancing Activation of the NF-κB Signaling Pathway.
Pyruvate Kinase M2 Protects Heart from Pressure Overload-Induced Heart Failure by Phosphorylating RAC1.
Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.
Glycomics reveal that ST6GAL1-mediated sialylation regulates uterine lumen closure during implantation.
Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.
Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin.
TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8(+) memory T cells.
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
MicroRNA-200b/c-3p regulate epithelial plasticity and inhibit cutaneous wound healing by modulating TGF-β-mediated RAC1 signaling.
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Kidney targeted delivery of asiatic acid using a FITC labeled renal tubular-targeting peptide modified PLGA-PEG system.
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells.
Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.
Louie JD, Barrios-Camacho CM, Bromberg BH, Hintschich CA, Schwob JE
iScience 2024 May 17;27(5):109600
iScience 2024 May 17;27(5):109600
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape.
Okabe M, Sato T, Takahashi M, Honjo A, Okawa M, Ishida M, Kukimoto-Niino M, Shirouzu M, Miyamoto Y, Yamauchi J
Current issues in molecular biology 2024 Apr 2;46(4):3092-3107
Current issues in molecular biology 2024 Apr 2;46(4):3092-3107
Caffeic acid phenethyl ester ameliorates titanium particle-induced bone loss and inflammatory reaction in a mouse acute model.
Xu X, Li L, Wang B, Shi B
Biochemical and biophysical research communications 2023 Nov 12;681:47-54
Biochemical and biophysical research communications 2023 Nov 12;681:47-54
Long Noncoding RNA AC078850.1 Induces NLRP3 Inflammasome-Mediated Pyroptosis in Atherosclerosis by Upregulating ITGB2 Transcription via Transcription Factor HIF-1α.
Tian Y, Luo Q, Huang K, Sun T, Luo S
Biomedicines 2023 Jun 16;11(6)
Biomedicines 2023 Jun 16;11(6)
DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells.
Wang Y, Wei M, Su M, Du Z, Dong J, Zhang Y, Wu Y, Li X, Su L, Liu X
iScience 2023 Jul 21;26(7):107157
iScience 2023 Jul 21;26(7):107157
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Liu D, Lin S, Li Y, Zhou T, Hu K, Li Q
Drug design, development and therapy 2022;16:375-395
Drug design, development and therapy 2022;16:375-395
Single-cell RNA sequencing of CSF reveals neuroprotective RAC1(+) NK cells in Parkinson's disease.
Guan Q, Liu W, Mu K, Hu Q, Xie J, Cheng L, Wang X
Frontiers in immunology 2022;13:992505
Frontiers in immunology 2022;13:992505
New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1.
Ye L, Song J, Zheng Y, Zhong M, Liu J, Zhu D, Hu S
Stem cell research & therapy 2022 Oct 8;13(1):496
Stem cell research & therapy 2022 Oct 8;13(1):496
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Zhou W, Wu WH, Si ZL, Liu HL, Wang H, Jiang H, Liu YF, Alolga RN, Chen C, Liu SJ, Bian XY, Shan JJ, Li J, Tan NH, Zhang ZH
Nature communications 2022 Oct 14;13(1):6081
Nature communications 2022 Oct 14;13(1):6081
SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion.
Zhang YY, Liang R, Wang SJ, Ye ZW, Wang TY, Chen M, Liu J, Na L, Yang YL, Yang YB, Yuan S, Yin X, Cai XH, Tang YD
The Journal of biological chemistry 2022 Nov;298(11):102511
The Journal of biological chemistry 2022 Nov;298(11):102511
SYTL5 Promotes Papillary Thyroid Carcinoma Progression by Enhancing Activation of the NF-κB Signaling Pathway.
Huang D, Zeng Y, Deng HY, Fu BD, Ke Y, Luo JY, Yu JC, Yu ST
Endocrinology 2022 Nov 14;164(1)
Endocrinology 2022 Nov 14;164(1)
Pyruvate Kinase M2 Protects Heart from Pressure Overload-Induced Heart Failure by Phosphorylating RAC1.
Ni L, Lin B, Hu L, Zhang R, Fu F, Shen M, Yang J, Shi D
Journal of the American Heart Association 2022 Jun 7;11(11):e024854
Journal of the American Heart Association 2022 Jun 7;11(11):e024854
Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.
Wolff DW, Deng Z, Bianchi-Smiraglia A, Foley CE, Han Z, Wang X, Shen S, Rosenberg MM, Moparthy S, Yun DH, Chen J, Baker BK, Roll MV, Magiera AJ, Li J, Hurley E, Feltri ML, Cox AO, Lee J, Furdui CM, Liu L, Bshara W, LaConte LEW, Kandel ES, Pasquale EB, Qu J, Hedstrom L, Nikiforov MA
Cell chemical biology 2022 Jun 16;29(6):970-984.e6
Cell chemical biology 2022 Jun 16;29(6):970-984.e6
Glycomics reveal that ST6GAL1-mediated sialylation regulates uterine lumen closure during implantation.
Han K, Wang F, Yue Y, Tan X, Tian M, Miao Y, Zhao S, Dong W, Yu M
Cell proliferation 2022 Jan;55(1):e13169
Cell proliferation 2022 Jan;55(1):e13169
Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.
Jin X, Zhang B, Zhang H, Yu H
Oncogene 2022 Jan;41(4):538-549
Oncogene 2022 Jan;41(4):538-549
Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin.
Alalem M, Bhosale M, Ranjan A, Yamamoto S, Kaida A, Nishikawa S, Parrales A, Farooki S, Anant S, Padhye S, Iwakuma T
Cancers 2022 Aug 29;14(17)
Cancers 2022 Aug 29;14(17)
TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8(+) memory T cells.
Zhang H, Liu J, Yang Z, Zeng L, Wei K, Zhu L, Tang L, Wang D, Zhou Y, Lv J, Zhou N, Tang K, Ma J, Huang B
Molecular cell 2022 Aug 18;82(16):3077-3088.e6
Molecular cell 2022 Aug 18;82(16):3077-3088.e6
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Ying C, Dai J, Fan G, Zhou Z, Gan T, Zhang Y, Song Y, Zhou X
Frontiers in physiology 2021;12:679166
Frontiers in physiology 2021;12:679166
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Bianchi-Smiraglia A, Wolff DW, Marston DJ, Deng Z, Han Z, Moparthy S, Wombacher RM, Mussell AL, Shen S, Chen J, Yun DH, O'Brien Cox A, Furdui CM, Hurley E, Feltri ML, Qu J, Hollis T, Kengne JBN, Fongang B, Sousa RJ, Kandel ME, Kandel ES, Hahn KM, Nikiforov MA
Nature communications 2021 Oct 19;12(1):6091
Nature communications 2021 Oct 19;12(1):6091
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
Lyu L, Chen J, Wang W, Yan T, Lin J, Gao H, Li H, Lv R, Xu F, Fang L, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.
Geng J, Shi Y, Zhang J, Yang B, Wang P, Yuan W, Zhao H, Li J, Qin F, Hong L, Xie C, Deng X, Sun Y, Wu C, Chen L, Zhou D
Nature communications 2021 Jun 10;12(1):3519
Nature communications 2021 Jun 10;12(1):3519
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
Hu X, Xiang L, He D, Zhu R, Fang J, Wang Z, Cao K
Clinical science (London, England : 1979) 2021 Feb 12;135(3):555-574
Clinical science (London, England : 1979) 2021 Feb 12;135(3):555-574
MicroRNA-200b/c-3p regulate epithelial plasticity and inhibit cutaneous wound healing by modulating TGF-β-mediated RAC1 signaling.
Tang H, Wang X, Zhang M, Yan Y, Huang S, Ji J, Xu J, Zhang Y, Cai Y, Yang B, Lan W, Huang M, Zhang L
Cell death & disease 2020 Oct 29;11(10):931
Cell death & disease 2020 Oct 29;11(10):931
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Zhang ZH, He JQ, Zhao YY, Chen HC, Tan NH
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Kidney targeted delivery of asiatic acid using a FITC labeled renal tubular-targeting peptide modified PLGA-PEG system.
He J, Chen H, Zhou W, Chen M, Yao Y, Zhang Z, Tan N
International journal of pharmaceutics 2020 Jun 30;584:119455
International journal of pharmaceutics 2020 Jun 30;584:119455
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
Huang D, Siaw-Debrah F, Wang H, Ye S, Wang K, Wu K, Zhang Y, Wang H, Yao C, Chen J, Yan L, Zhang CL, Zhuge Q, Yang J
Aging 2020 Dec 19;13(2):2822-2850
Aging 2020 Dec 19;13(2):2822-2850
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
Tian F, Wang Z, He J, Zhang Z, Tan N
European journal of pharmacology 2020 Apr 15;873:172989
European journal of pharmacology 2020 Apr 15;873:172989
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Wudu M, Ren H, Hui L, Jiang J, Zhang S, Xu Y, Wang Q, Su H, Jiang X, Dao R, Qiu X
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
Ma D, Zheng B, Suzuki T, Zhang R, Jiang C, Bai D, Yin W, Yang Z, Zhang X, Hou L, Zhan H, Wen JK
Circulation research 2017 Mar 3;120(5):799-815
Circulation research 2017 Mar 3;120(5):799-815
The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells.
Li J, Zhang S, Hu Q, Zhang K, Jin J, Zheng X, Yin Z, Wang X
Scientific reports 2016 May 27;6:26971
Scientific reports 2016 May 27;6:26971
Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.
Zhou T, Zhang B, Wei P, Du Y, Zhou H, Yu M, Yan L, Zhang W, Nie G, Chen C, Tu Y, Wei T
Biomaterials 2014 Dec;35(37):9833-9843
Biomaterials 2014 Dec;35(37):9833-9843
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Rac1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human Rac1. This antibody recognizes human,mouse antigen. The Rac1 antibody has been validated for the following applications: ELISA, WB analysis.
