MB0119

antibody from Bioworld Technology, Inc
Targeting: BMI1 PCGF4, RNF51
Provider product page for MB0119

Antibody data

Product number
MB0119 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BMI1 monoclonal antibody
Antibody type
Monoclonal
Antigen
Recombinant full length Human BMI1.
Description
Mel-18 and Bmi-1 are mammalian homologs of Drosophila Pc-g group proteins, as they are similarly expressed during development and implicated in the regulation of gene expression, axial skeleton development, and the control of proliferation and survival of hematopoietic cells. Mel-18 directly binds to DNA through a ring-finger motif and preferentially associates with juxtaposed enhancer elements on various genes, including Bcl-2, c-Myc and Hox. Mel-18 is an immediate early response gene within the c-Myc/Cdc25 signaling cascade that exhibits tumor suppressor activity and negatively regulates cell cycle progression by blocking S phase entry. Alternatively, Bmi-1 has been identified as a potent oncogene as it contributes to the transcriptional activation of genes implicated in early lymphoid development.
Reactivity
Human
Host
Mouse
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BMI1 protein structure - MB0119 shown in red.