M00511

antibody from Boster Biological Technology
Targeting: CDK5 PSSALRE
Provider product page for M00511
Western blot
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
M00511 - Provider product page
Provider
Boster Biological Technology
Product name
Anti-CDK5 Rabbit Monoclonal Antibody
Antibody type
Monoclonal
Description
Monoclonal antibody for CDK5 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: Flow Cytometry, IP, IHC, WB. Reactive species: Human, Mouse, Rat CDK5 information: Molecular Weight: 33304 MW; Subcellular Localization: Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium . Cell projection, growth cone . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this att
Reactivity
Human, Mouse, Rat
Host
Rabbit
Antibody clone number
DAH-3
Vial size
100ug/vial
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage
At -20°C for one year. Avoid repeated freezing and thawing.
CDK5 protein structure - M00511 shown in red.