AMM03624G

antibody from Leading Biology

Targeting: HLA-DPA1 HLA-DP1A

Western blot (Recommended by provider)

Antibody Data

Product number

AMM03624G

Provider

Leading Biology

Product name

HLA-DPA1 Antibody (monoclonal) (M03)

Antibody type

Monoclonal

Description

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

1E4

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.