60011AD

antibody from STEMCELL Technologies Inc
Targeting: CD3D T3D
Provider product page for 60011AD
Immunocytochemistry
Flow cytometry

Antibody data

Product number
60011AD - Provider product page
Provider
STEMCELL Technologies Inc
Product name
Anti-Human CD3 Antibody, Clone UCHT1, Alexa Fluor® 488
Antibody type
Monoclonal
Description
The UCHT1 antibody reacts with the ~20 kDa CD3? subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex, which is assembled from combinations of CD3?, ?, ?, ?, and ? subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders including severe combined immunodeficiency (SCID). This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Direct Human T Cell Isolation Kit (Catalog #19661), EasySep™ Human CD3 Positive Selection Kit II (Catalog #17851; partial blocking may be observed), EasySep™ HLA Whole Blood T Cell Enrichment Kit (Catalog #19951HLA) and EasySep™ HLA Whole Blood CD2 Positive Selection Kit (Catalog #18687HLA).
Reactivity
Human
Isotype
IgG
Vial size
100 Tests
Storage
2 - 8°C
CD3D protein structure - 60011AD shown in red.