BS8488

antibody from Bioworld Technology, Inc
Targeting: PDLIM5 Enh, LIM
Provider product page for BS8488
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8488 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PDLIM5 polyclonal antibody
Antibody type
Polyclonal
Antigen
PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein; PDLIM5; ENH; L9
Description
PDLIM5 (PDZ and LIM domain 5), also known as L9, ENH (Enigma homolog),LIM or ENH1, is a member of the Enigma family of proteins. Proteins belonging to this family contain an N-terminal PDZ (post-synaptic density-95/discs large/zone occludens-1) domain and one to three C-terminal LIM domains that typically associate with various isoforms of PKC (protein kinase C). Expressed in a wide variety of tissues, PDLIM5 contains three LIM zinc-binding domains and one PDZ domain. In the brain, PDLIM5 colocalizes with synaptic vesicles of neurotransmitters and regulates neuronal calcium signaling through an interaction with PKC š÷ and N-type Ca++ CP Ï«1B (N-type calcium channel Ï«1B subunit). Expression of PDLIM5 is often increased in the brain of patients with schizophrenia, major depression and bipolar disorder. This suggests that PDLIM5 may contribute to the genetic susceptibility of such conditions.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PDLIM5 protein structure - BS8488 shown in red.